Extracellular Vesicles in Innate Immune Cell Programming
Extracellular vesicles (EV) are a heterogeneous group of bilipid-enclosed envelopes that carry proteins, metabolites, RNA, DNA and lipids from their parent cell of origin. They mediate cellular communication to other cells in local tissue microenvironments and across organ systems. EV size, number a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/7/713 |
| _version_ | 1827689024142180352 |
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| author | Naveed Akbar Daan Paget Robin P. Choudhury |
| author_facet | Naveed Akbar Daan Paget Robin P. Choudhury |
| author_sort | Naveed Akbar |
| collection | DOAJ |
| description | Extracellular vesicles (EV) are a heterogeneous group of bilipid-enclosed envelopes that carry proteins, metabolites, RNA, DNA and lipids from their parent cell of origin. They mediate cellular communication to other cells in local tissue microenvironments and across organ systems. EV size, number and their biologically active cargo are often altered in response to pathological processes, including infection, cancer, cardiovascular diseases and in response to metabolic perturbations such as obesity and diabetes, which also have a strong inflammatory component. Here, we discuss the broad repertoire of EV produced by neutrophils, monocytes, macrophages, their precursor hematopoietic stem cells and discuss their effects on the innate immune system. We seek to understand the immunomodulatory properties of EV in cellular programming, which impacts innate immune cell differentiation and function. We further explore the possibilities of using EV as immune targeting vectors, for the modulation of the innate immune response, e.g., for tissue preservation during sterile injury such as myocardial infarction or to promote tissue resolution of inflammation and potentially tissue regeneration and repair. |
| first_indexed | 2024-03-10T10:08:48Z |
| format | Article |
| id | doaj.art-bacbad26ba384f32a64b74ca08c398db |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T10:08:48Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-bacbad26ba384f32a64b74ca08c398db2023-11-22T01:21:48ZengMDPI AGBiomedicines2227-90592021-06-019771310.3390/biomedicines9070713Extracellular Vesicles in Innate Immune Cell ProgrammingNaveed Akbar0Daan Paget1Robin P. Choudhury2Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UKRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UKRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UKExtracellular vesicles (EV) are a heterogeneous group of bilipid-enclosed envelopes that carry proteins, metabolites, RNA, DNA and lipids from their parent cell of origin. They mediate cellular communication to other cells in local tissue microenvironments and across organ systems. EV size, number and their biologically active cargo are often altered in response to pathological processes, including infection, cancer, cardiovascular diseases and in response to metabolic perturbations such as obesity and diabetes, which also have a strong inflammatory component. Here, we discuss the broad repertoire of EV produced by neutrophils, monocytes, macrophages, their precursor hematopoietic stem cells and discuss their effects on the innate immune system. We seek to understand the immunomodulatory properties of EV in cellular programming, which impacts innate immune cell differentiation and function. We further explore the possibilities of using EV as immune targeting vectors, for the modulation of the innate immune response, e.g., for tissue preservation during sterile injury such as myocardial infarction or to promote tissue resolution of inflammation and potentially tissue regeneration and repair.https://www.mdpi.com/2227-9059/9/7/713exosomestranscriptionneutrophilmonocytehematopoietic stem cell |
| spellingShingle | Naveed Akbar Daan Paget Robin P. Choudhury Extracellular Vesicles in Innate Immune Cell Programming Biomedicines exosomes transcription neutrophil monocyte hematopoietic stem cell |
| title | Extracellular Vesicles in Innate Immune Cell Programming |
| title_full | Extracellular Vesicles in Innate Immune Cell Programming |
| title_fullStr | Extracellular Vesicles in Innate Immune Cell Programming |
| title_full_unstemmed | Extracellular Vesicles in Innate Immune Cell Programming |
| title_short | Extracellular Vesicles in Innate Immune Cell Programming |
| title_sort | extracellular vesicles in innate immune cell programming |
| topic | exosomes transcription neutrophil monocyte hematopoietic stem cell |
| url | https://www.mdpi.com/2227-9059/9/7/713 |
| work_keys_str_mv | AT naveedakbar extracellularvesiclesininnateimmunecellprogramming AT daanpaget extracellularvesiclesininnateimmunecellprogramming AT robinpchoudhury extracellularvesiclesininnateimmunecellprogramming |