IL-6 predicts organ dysfunction and mortality in patients with multiple injuries
<p>Abstract</p> <p>Background</p> <p>Although therapeutic concepts of patients with major trauma have improved during recent years, organ dysfunction still remains a frequent complication during clinical course in intensive care units. It has previously been shown that...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-09-01
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| Series: | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
| Online Access: | http://www.sjtrem.com/content/17/1/49 |
| _version_ | 1818212598618783744 |
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| author | Vaske Bernhard Zeckey Christian Brin Thomas Kobbe Philipp van Griensven Martijn Frink Michael Krettek Christian Hildebrand Frank |
| author_facet | Vaske Bernhard Zeckey Christian Brin Thomas Kobbe Philipp van Griensven Martijn Frink Michael Krettek Christian Hildebrand Frank |
| author_sort | Vaske Bernhard |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Although therapeutic concepts of patients with major trauma have improved during recent years, organ dysfunction still remains a frequent complication during clinical course in intensive care units. It has previously been shown that cytokines are upregulated under stress conditions such as trauma or sepsis. However, it is still debatable if cytokines are adequate parameters to describe the current state of trauma patients. To elucidate the relevance of cytokines, we investigated if cytokines predict development of multiple organ dysfunction syndrome (MODS) or outcome.</p> <p>Methods</p> <p>A total of 143 patients with an injury severity score ≥ 16, between 16 and 65 years, admitted to the Hannover Medical School Level 1 Trauma Center between January 1997 and December 2001 were prospectively included in this study. Marshall Score for MODS was calculated for at least 14 days and plasma levels of TNF-α, IL-1β, IL-6, IL-8 and IL-10 were measured. To determine the association between cytokine levels and development of MODS the Spearman rank correlation coefficient was calculated and logistic regression and analysis were performed.</p> <p>Results and Discussion</p> <p>Patients with MODS had increased plasma levels of IL-6, IL-8 and IL-10. IL-6 predicted development of MODS with an overall accuracy of 84.7% (specificity: 98.3%, sensitivity: 16.7%). The threshold value for development of MODS was 761.7 pg/ml and 2176.0 pg/ml for mortality during the in patient time.</p> <p>Conclusion</p> <p>We conclude that plasma IL-6 levels predict mortality and that they are a useful tool to identify patients who are at risk for development of MODS.</p> |
| first_indexed | 2024-12-12T05:50:57Z |
| format | Article |
| id | doaj.art-bacc5ddc9dad49b4a5c6f8f35fef7b2c |
| institution | Directory Open Access Journal |
| issn | 1757-7241 |
| language | English |
| last_indexed | 2024-12-12T05:50:57Z |
| publishDate | 2009-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
| spelling | doaj.art-bacc5ddc9dad49b4a5c6f8f35fef7b2c2022-12-22T00:35:41ZengBMCScandinavian Journal of Trauma, Resuscitation and Emergency Medicine1757-72412009-09-011714910.1186/1757-7241-17-49IL-6 predicts organ dysfunction and mortality in patients with multiple injuriesVaske BernhardZeckey ChristianBrin ThomasKobbe Philippvan Griensven MartijnFrink MichaelKrettek ChristianHildebrand Frank<p>Abstract</p> <p>Background</p> <p>Although therapeutic concepts of patients with major trauma have improved during recent years, organ dysfunction still remains a frequent complication during clinical course in intensive care units. It has previously been shown that cytokines are upregulated under stress conditions such as trauma or sepsis. However, it is still debatable if cytokines are adequate parameters to describe the current state of trauma patients. To elucidate the relevance of cytokines, we investigated if cytokines predict development of multiple organ dysfunction syndrome (MODS) or outcome.</p> <p>Methods</p> <p>A total of 143 patients with an injury severity score ≥ 16, between 16 and 65 years, admitted to the Hannover Medical School Level 1 Trauma Center between January 1997 and December 2001 were prospectively included in this study. Marshall Score for MODS was calculated for at least 14 days and plasma levels of TNF-α, IL-1β, IL-6, IL-8 and IL-10 were measured. To determine the association between cytokine levels and development of MODS the Spearman rank correlation coefficient was calculated and logistic regression and analysis were performed.</p> <p>Results and Discussion</p> <p>Patients with MODS had increased plasma levels of IL-6, IL-8 and IL-10. IL-6 predicted development of MODS with an overall accuracy of 84.7% (specificity: 98.3%, sensitivity: 16.7%). The threshold value for development of MODS was 761.7 pg/ml and 2176.0 pg/ml for mortality during the in patient time.</p> <p>Conclusion</p> <p>We conclude that plasma IL-6 levels predict mortality and that they are a useful tool to identify patients who are at risk for development of MODS.</p>http://www.sjtrem.com/content/17/1/49 |
| spellingShingle | Vaske Bernhard Zeckey Christian Brin Thomas Kobbe Philipp van Griensven Martijn Frink Michael Krettek Christian Hildebrand Frank IL-6 predicts organ dysfunction and mortality in patients with multiple injuries Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
| title | IL-6 predicts organ dysfunction and mortality in patients with multiple injuries |
| title_full | IL-6 predicts organ dysfunction and mortality in patients with multiple injuries |
| title_fullStr | IL-6 predicts organ dysfunction and mortality in patients with multiple injuries |
| title_full_unstemmed | IL-6 predicts organ dysfunction and mortality in patients with multiple injuries |
| title_short | IL-6 predicts organ dysfunction and mortality in patients with multiple injuries |
| title_sort | il 6 predicts organ dysfunction and mortality in patients with multiple injuries |
| url | http://www.sjtrem.com/content/17/1/49 |
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