The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a common systemic autoimmune disease. Its major manifestation is persistent joint inflammation, which can lead to bone destruction and severe disability. The immunopathogenesis of RA is very complex, involving both innate and adaptive immune systems. Recently, the discov...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=1;spage=5;epage=10;aulast=Yu |
| _version_ | 1818480786613993472 |
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| author | Hui-Chun Yu Ming-Chi Lu |
| author_facet | Hui-Chun Yu Ming-Chi Lu |
| author_sort | Hui-Chun Yu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a common systemic autoimmune disease. Its major manifestation is persistent joint inflammation, which can lead to bone destruction and severe disability. The immunopathogenesis of RA is very complex, involving both innate and adaptive immune systems. Recently, the discovery of anti-citrullinated protein antibodies (ACPAs) has revolutionized the diagnosis and our understanding of the immunopathogenesis of RA. The presence of ACPAs is also closely linked to the disease activity of RA. Therefore, it is reasonable to believe that ACPAs and protein citrullination are key issues for the development of RA. We have summarized the recent study results in this review. The first theory concerning the pathogenesis of RA proposed that ACPAs link the well-known genetic and environmental risk factors for developing RA. However, due to the close association between joint inflammation and ACPAs, a more direct role of ACPAs in the immunopathogenesis of RA is anticipated. Within the past 10 years, many studies, including some of our own, have shown that ACPAs can promote an inflammatory response through complement activation, formation of neutrophil extracellular traps, and direct binding to key players, including monocytes, osteoclasts, and osteoblasts, in the mediation of bone destruction in the joints of RA patients. We also present some new perspectives and issues that need to be further investigated. |
| first_indexed | 2024-12-10T11:26:58Z |
| format | Article |
| id | doaj.art-bace1568bb714af690a76797b971483f |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-10T11:26:58Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-bace1568bb714af690a76797b971483f2022-12-22T01:50:42ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562019-01-0131151010.4103/tcmj.tcmj_116_18The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritisHui-Chun YuMing-Chi LuRheumatoid arthritis (RA) is a common systemic autoimmune disease. Its major manifestation is persistent joint inflammation, which can lead to bone destruction and severe disability. The immunopathogenesis of RA is very complex, involving both innate and adaptive immune systems. Recently, the discovery of anti-citrullinated protein antibodies (ACPAs) has revolutionized the diagnosis and our understanding of the immunopathogenesis of RA. The presence of ACPAs is also closely linked to the disease activity of RA. Therefore, it is reasonable to believe that ACPAs and protein citrullination are key issues for the development of RA. We have summarized the recent study results in this review. The first theory concerning the pathogenesis of RA proposed that ACPAs link the well-known genetic and environmental risk factors for developing RA. However, due to the close association between joint inflammation and ACPAs, a more direct role of ACPAs in the immunopathogenesis of RA is anticipated. Within the past 10 years, many studies, including some of our own, have shown that ACPAs can promote an inflammatory response through complement activation, formation of neutrophil extracellular traps, and direct binding to key players, including monocytes, osteoclasts, and osteoblasts, in the mediation of bone destruction in the joints of RA patients. We also present some new perspectives and issues that need to be further investigated.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=1;spage=5;epage=10;aulast=YuAnti-citrullinated protein antibodiesCitrullinationPeptidylarginine deiminaseRheumatoid arthritis |
| spellingShingle | Hui-Chun Yu Ming-Chi Lu The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis Tzu-Chi Medical Journal Anti-citrullinated protein antibodies Citrullination Peptidylarginine deiminase Rheumatoid arthritis |
| title | The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis |
| title_full | The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis |
| title_fullStr | The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis |
| title_full_unstemmed | The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis |
| title_short | The roles of anti-citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis |
| title_sort | roles of anti citrullinated protein antibodies in the immunopathogenesis of rheumatoid arthritis |
| topic | Anti-citrullinated protein antibodies Citrullination Peptidylarginine deiminase Rheumatoid arthritis |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2019;volume=31;issue=1;spage=5;epage=10;aulast=Yu |
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