Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo
The noradrenergic system plays numerous physiological roles but tools to study it are scarce. Here the authors develop a fluorescent analogue of norepinephrine that can be used to label noradrenergic neurons and the synaptic vesicles, and use it to measure single synaptic vesicle release sites in li...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05075-x |
| _version_ | 1818977836044648448 |
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| author | Matthew Dunn Adam Henke Samuel Clark Yekaterina Kovalyova Kimberly A. Kempadoo Richard J. Karpowicz Eric R. Kandel David Sulzer Dalibor Sames |
| author_facet | Matthew Dunn Adam Henke Samuel Clark Yekaterina Kovalyova Kimberly A. Kempadoo Richard J. Karpowicz Eric R. Kandel David Sulzer Dalibor Sames |
| author_sort | Matthew Dunn |
| collection | DOAJ |
| description | The noradrenergic system plays numerous physiological roles but tools to study it are scarce. Here the authors develop a fluorescent analogue of norepinephrine that can be used to label noradrenergic neurons and the synaptic vesicles, and use it to measure single synaptic vesicle release sites in living mice. |
| first_indexed | 2024-12-20T16:34:04Z |
| format | Article |
| id | doaj.art-bace60ad7e2a435b90bdc647f50746aa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:34:04Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bace60ad7e2a435b90bdc647f50746aa2022-12-21T19:33:12ZengNature PortfolioNature Communications2041-17232018-07-019111310.1038/s41467-018-05075-xDesigning a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivoMatthew Dunn0Adam Henke1Samuel Clark2Yekaterina Kovalyova3Kimberly A. Kempadoo4Richard J. Karpowicz5Eric R. Kandel6David Sulzer7Dalibor Sames8Department of Chemistry, Columbia UniversityDepartment of Chemistry, Columbia UniversityDepartment of Neurology, Columbia UniversityDepartment of Chemistry, Columbia UniversityDepartment of Neuroscience, Columbia UniversityDepartment of Chemistry, Columbia UniversityDepartment of Psychiatry, Columbia UniversityDepartment of Neurology, Columbia UniversityDepartment of Chemistry, Columbia UniversityThe noradrenergic system plays numerous physiological roles but tools to study it are scarce. Here the authors develop a fluorescent analogue of norepinephrine that can be used to label noradrenergic neurons and the synaptic vesicles, and use it to measure single synaptic vesicle release sites in living mice.https://doi.org/10.1038/s41467-018-05075-x |
| spellingShingle | Matthew Dunn Adam Henke Samuel Clark Yekaterina Kovalyova Kimberly A. Kempadoo Richard J. Karpowicz Eric R. Kandel David Sulzer Dalibor Sames Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo Nature Communications |
| title | Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo |
| title_full | Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo |
| title_fullStr | Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo |
| title_full_unstemmed | Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo |
| title_short | Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo |
| title_sort | designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo |
| url | https://doi.org/10.1038/s41467-018-05075-x |
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