Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study
Shufang Lin,1,2 Shuzhen Wei,1,2 Yong Zhao,1,2 Jian Lin,1,2 Yu Pang3 1Institute of Tuberculosis Control and Prevention, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 2Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Con...
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| Format: | Article |
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Dove Medical Press
2019-11-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/epidemiology-of-human-pulmonary-infection-with-nontuberculous-mycobact-peer-reviewed-article-IDR |
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| author | Lin S Wei S Zhao Y Lin J Pang Y |
| author_facet | Lin S Wei S Zhao Y Lin J Pang Y |
| author_sort | Lin S |
| collection | DOAJ |
| description | Shufang Lin,1,2 Shuzhen Wei,1,2 Yong Zhao,1,2 Jian Lin,1,2 Yu Pang3 1Institute of Tuberculosis Control and Prevention, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 2Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 3National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People’s Republic of ChinaCorrespondence: Shufang LinInstitute of Tuberculosis Control and Prevention, Fujian Center for Disease Control and Prevention, No. 76, Jintai Road, Gulou District, Fuzhou, Fujian 350001, People’s Republic of ChinaTel/Fax +86 591 8343 1464Email zqszl@163.com
Yu PangBeijing Chest Hospital, Capital Medical University, No. 97, Machang, Tongzhou District, Beijing 101149, People’s Republic of ChinaTel/Fax +86 10 8950 9359Email pangyupound@163.comBackground: China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian.Methods: The mycobacterial isolates were collected from the tuberculosis survey from Fujian Province conducted between July 1, 2010 and June 30, 2011.Results: From July 1, 2010 to June 30, 2011, 1425 isolates were included in the final analysis, of which 60 (4.2%) were identified as NTM species. M. intracellulare was the most frequently isolated NTM in Fujian, accounting for 68.3% of all NTM isolates. Compared with patients aged <45 years, patients aged 45–59 were more likely to have NTM infections. The education level of patients had an impact on the distribution of NTM infections. Illiterate patients had significantly higher odds of having NTM compared to literate patients. Patients with a previous TB episode had higher NTM risk as compared to those without previous TB episodes.Conclusion: In conclusion, the predominant NTM is M. intracellulare among patients with presumptive TB in Fujian. In addition, elderly patients, those with a previous TB episode and illiterate patients have higher NTM risk.Keywords: nontuberculous mycobacteria, prevalence, risk factor |
| first_indexed | 2024-12-11T08:47:08Z |
| format | Article |
| id | doaj.art-bace7d6c919b4951ac46e27a8d854517 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T08:47:08Z |
| publishDate | 2019-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-bace7d6c919b4951ac46e27a8d8545172022-12-22T01:14:06ZengDove Medical PressInfection and Drug Resistance1178-69732019-11-01Volume 123515352149714Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance StudyLin SWei SZhao YLin JPang YShufang Lin,1,2 Shuzhen Wei,1,2 Yong Zhao,1,2 Jian Lin,1,2 Yu Pang3 1Institute of Tuberculosis Control and Prevention, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 2Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 3National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, People’s Republic of ChinaCorrespondence: Shufang LinInstitute of Tuberculosis Control and Prevention, Fujian Center for Disease Control and Prevention, No. 76, Jintai Road, Gulou District, Fuzhou, Fujian 350001, People’s Republic of ChinaTel/Fax +86 591 8343 1464Email zqszl@163.com Yu PangBeijing Chest Hospital, Capital Medical University, No. 97, Machang, Tongzhou District, Beijing 101149, People’s Republic of ChinaTel/Fax +86 10 8950 9359Email pangyupound@163.comBackground: China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian.Methods: The mycobacterial isolates were collected from the tuberculosis survey from Fujian Province conducted between July 1, 2010 and June 30, 2011.Results: From July 1, 2010 to June 30, 2011, 1425 isolates were included in the final analysis, of which 60 (4.2%) were identified as NTM species. M. intracellulare was the most frequently isolated NTM in Fujian, accounting for 68.3% of all NTM isolates. Compared with patients aged <45 years, patients aged 45–59 were more likely to have NTM infections. The education level of patients had an impact on the distribution of NTM infections. Illiterate patients had significantly higher odds of having NTM compared to literate patients. Patients with a previous TB episode had higher NTM risk as compared to those without previous TB episodes.Conclusion: In conclusion, the predominant NTM is M. intracellulare among patients with presumptive TB in Fujian. In addition, elderly patients, those with a previous TB episode and illiterate patients have higher NTM risk.Keywords: nontuberculous mycobacteria, prevalence, risk factorhttps://www.dovepress.com/epidemiology-of-human-pulmonary-infection-with-nontuberculous-mycobact-peer-reviewed-article-IDRnontuberculous mycobacteriaprevalencerisk factor |
| spellingShingle | Lin S Wei S Zhao Y Lin J Pang Y Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study Infection and Drug Resistance nontuberculous mycobacteria prevalence risk factor |
| title | Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study |
| title_full | Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study |
| title_fullStr | Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study |
| title_full_unstemmed | Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study |
| title_short | Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study |
| title_sort | epidemiology of human pulmonary infection with nontuberculous mycobacteria in southeast china a prospective surveillance study |
| topic | nontuberculous mycobacteria prevalence risk factor |
| url | https://www.dovepress.com/epidemiology-of-human-pulmonary-infection-with-nontuberculous-mycobact-peer-reviewed-article-IDR |
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