The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review
Human immunodeficiency virus (HIV) especially HIV-1 infection and its progression to acquired immune deficiency syndrome (AIDS) remains a significant global health challenge. The advent of the highly active antiretroviral therapy (HAART) has greatly extended the life expectancy of patients living wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222005585 |
| _version_ | 1811250748250390528 |
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| author | Cui Deng Heng Yan Jun Wang Bao-shan Liu Kai Liu Yu-min Shi |
| author_facet | Cui Deng Heng Yan Jun Wang Bao-shan Liu Kai Liu Yu-min Shi |
| author_sort | Cui Deng |
| collection | DOAJ |
| description | Human immunodeficiency virus (HIV) especially HIV-1 infection and its progression to acquired immune deficiency syndrome (AIDS) remains a significant global health challenge. The advent of the highly active antiretroviral therapy (HAART) has greatly extended the life expectancy of patients living with HIV, but it has become evident that long-term HAART will not eliminate the HIV reservoir and cure the infection. Moreover, the drug resistance and undesirable side effects hamper efficacious therapy, creating an urgent need to develop novel, more effective and less toxic anti-HIV therapeutics. Imidazole, oxazole and thiazole with two heteroatoms at meta-position of five-membered rings are fascinating structures and constitute an important class of heterocycles in drug discovery. Their derivatives could exert the anti-HIV activity through diverse mechanisms and possess promising antiviral activity against both drug-sensitive and drug-resistant HIV strains. This review summarizes the research progress made regarding the anti-HIV potential of imidazole, oxazole and thiazole hybrids, and the structure–activity relationships (SARs) are also discussed to facilitate further rational design of more effective candidates, covering articles published from 2012 to 2022. |
| first_indexed | 2024-04-12T16:09:16Z |
| format | Article |
| id | doaj.art-bad0193185464a3695542bb5d3bc5311 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-12T16:09:16Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-bad0193185464a3695542bb5d3bc53112022-12-22T03:25:57ZengElsevierArabian Journal of Chemistry1878-53522022-11-011511104242The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-reviewCui Deng0Heng Yan1Jun Wang2Bao-shan Liu3Kai Liu4Yu-min Shi5Hubei Engineering Research Center for Fragrant Plants, Hubei University of Science and Technology, Xianning, Hubei 437100, PR China; Xianning Research Academy of Industrial Technology of Osmanthus fragrans, Xianning, Hubei 437100, PR ChinaHubei Provincial Institute for Food Supervision and Test, Wuhan, Hubei 430070, PR ChinaHubei Engineering Research Center for Fragrant Plants, Hubei University of Science and Technology, Xianning, Hubei 437100, PR China; Xianning Research Academy of Industrial Technology of Osmanthus fragrans, Xianning, Hubei 437100, PR ChinaHubei Engineering Research Center for Fragrant Plants, Hubei University of Science and Technology, Xianning, Hubei 437100, PR China; Xianning Research Academy of Industrial Technology of Osmanthus fragrans, Xianning, Hubei 437100, PR ChinaHubei Engineering Research Center for Fragrant Plants, Hubei University of Science and Technology, Xianning, Hubei 437100, PR China; Xianning Research Academy of Industrial Technology of Osmanthus fragrans, Xianning, Hubei 437100, PR ChinaHubei Engineering Research Center for Fragrant Plants, Hubei University of Science and Technology, Xianning, Hubei 437100, PR China; Xianning Research Academy of Industrial Technology of Osmanthus fragrans, Xianning, Hubei 437100, PR China; Corresponding author.Human immunodeficiency virus (HIV) especially HIV-1 infection and its progression to acquired immune deficiency syndrome (AIDS) remains a significant global health challenge. The advent of the highly active antiretroviral therapy (HAART) has greatly extended the life expectancy of patients living with HIV, but it has become evident that long-term HAART will not eliminate the HIV reservoir and cure the infection. Moreover, the drug resistance and undesirable side effects hamper efficacious therapy, creating an urgent need to develop novel, more effective and less toxic anti-HIV therapeutics. Imidazole, oxazole and thiazole with two heteroatoms at meta-position of five-membered rings are fascinating structures and constitute an important class of heterocycles in drug discovery. Their derivatives could exert the anti-HIV activity through diverse mechanisms and possess promising antiviral activity against both drug-sensitive and drug-resistant HIV strains. This review summarizes the research progress made regarding the anti-HIV potential of imidazole, oxazole and thiazole hybrids, and the structure–activity relationships (SARs) are also discussed to facilitate further rational design of more effective candidates, covering articles published from 2012 to 2022.http://www.sciencedirect.com/science/article/pii/S1878535222005585Acquired immune deficiency syndromeHuman immunodeficiency virusImidazoleOxazoleThiazoleHybrid molecules |
| spellingShingle | Cui Deng Heng Yan Jun Wang Bao-shan Liu Kai Liu Yu-min Shi The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review Arabian Journal of Chemistry Acquired immune deficiency syndrome Human immunodeficiency virus Imidazole Oxazole Thiazole Hybrid molecules |
| title | The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review |
| title_full | The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review |
| title_fullStr | The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review |
| title_full_unstemmed | The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review |
| title_short | The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review |
| title_sort | anti hiv potential of imidazole oxazole and thiazole hybrids a mini review |
| topic | Acquired immune deficiency syndrome Human immunodeficiency virus Imidazole Oxazole Thiazole Hybrid molecules |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222005585 |
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