A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and in null mutants demonstrate a major impact of the trace amine-associated receptor 1 (Taar1) gene on a triad...

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Bibliographic Details
Main Authors: Cheryl Reed, Harue Baba, Zhen Zhu, Jason Erk, John R. Mootz, Nicholas M. Varra, Robert W. Williams, Tamara J. Phillips
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
addiction
BXD RI strains
conditioned taste aversion
drinking
hypothermia
selected lines
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00993/full

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