Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon)
Oral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to oral Trypanosoma cruzi transmission. Clinical and epid...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190364.pdf |
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| author | Valéria Regina Cavalcante dos Santos Dina Antunes Dilma do Socorro Moraes de Souza Otacilio Cruz Moreira Igor Campos de Almeida Lima Désio A Farias-de-Oliveira João Pedro Lobo Ernesto de Meis José Rodrigues Coura Wilson Savino Angela Cristina Verissimo Junqueira Juliana de Meis |
| author_facet | Valéria Regina Cavalcante dos Santos Dina Antunes Dilma do Socorro Moraes de Souza Otacilio Cruz Moreira Igor Campos de Almeida Lima Désio A Farias-de-Oliveira João Pedro Lobo Ernesto de Meis José Rodrigues Coura Wilson Savino Angela Cristina Verissimo Junqueira Juliana de Meis |
| author_sort | Valéria Regina Cavalcante dos Santos |
| collection | DOAJ |
| description | Oral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to oral Trypanosoma cruzi transmission. Clinical and epidemiological findings of 102 infected individuals attended in the State of Pará from October 2013 to February 2016 were included. The most common symptoms were fever (98%), asthenia (83.3%), face and limb edema (80.4%), headache (74.5%) and myalgia (72.5%). The hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of 30 ACD patients were higher compared with controls, and this increase was independent of the treatment with benznidazole. Moreover, ACD individuals had higher plasma levels of activated protein C and lower levels of factor VII of the coagulation cascade. Patients with the highest parasite load had also the most increased transaminase levels. Also, ALT and AST were associated moderately (r = 0.429) and strongly (r = 0.595) with parasite load respectively. In conclusion, the present study raises the possibility that a disturbance in coagulation and hepatic function may be linked to human ACD. |
| first_indexed | 2024-03-12T08:11:06Z |
| format | Article |
| id | doaj.art-bad6fccd5b334213ae2b7b893f36c514 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:06Z |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-bad6fccd5b334213ae2b7b893f36c5142023-09-02T19:07:04ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-806010.1590/0074-02760190364Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon)Valéria Regina Cavalcante dos SantosDina AntunesDilma do Socorro Moraes de SouzaOtacilio Cruz MoreiraIgor Campos de Almeida LimaDésio A Farias-de-OliveiraJoão Pedro LoboErnesto de MeisJosé Rodrigues CouraWilson SavinoAngela Cristina Verissimo JunqueiraJuliana de MeisOral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to oral Trypanosoma cruzi transmission. Clinical and epidemiological findings of 102 infected individuals attended in the State of Pará from October 2013 to February 2016 were included. The most common symptoms were fever (98%), asthenia (83.3%), face and limb edema (80.4%), headache (74.5%) and myalgia (72.5%). The hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of 30 ACD patients were higher compared with controls, and this increase was independent of the treatment with benznidazole. Moreover, ACD individuals had higher plasma levels of activated protein C and lower levels of factor VII of the coagulation cascade. Patients with the highest parasite load had also the most increased transaminase levels. Also, ALT and AST were associated moderately (r = 0.429) and strongly (r = 0.595) with parasite load respectively. In conclusion, the present study raises the possibility that a disturbance in coagulation and hepatic function may be linked to human ACD.http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190364.pdfChagas diseaseoral transmissionliver enzymescoagulation factorsparasite load |
| spellingShingle | Valéria Regina Cavalcante dos Santos Dina Antunes Dilma do Socorro Moraes de Souza Otacilio Cruz Moreira Igor Campos de Almeida Lima Désio A Farias-de-Oliveira João Pedro Lobo Ernesto de Meis José Rodrigues Coura Wilson Savino Angela Cristina Verissimo Junqueira Juliana de Meis Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon) Memorias do Instituto Oswaldo Cruz Chagas disease oral transmission liver enzymes coagulation factors parasite load |
| title | Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon) |
| title_full | Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon) |
| title_fullStr | Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon) |
| title_full_unstemmed | Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon) |
| title_short | Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon) |
| title_sort | human acute chagas disease changes in factor vii activated protein c and hepatic enzymes from patients of oral outbreaks in para state brazilian amazon |
| topic | Chagas disease oral transmission liver enzymes coagulation factors parasite load |
| url | http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190364.pdf |
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