An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity

An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity

Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier (BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic largely due to their low specificities and side effects. Here, we explored the therapeutic potential of a human IgG monoclonal...

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Bibliographic Details
Main Authors: Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Dengpan Song, Ruby L.C. Hoo, Zening Wang, Xin Ge, Hongjie Han, Fuyou Guo, Junlei Chang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Pharmacological Research
Subjects:
MMP-9
Ischemic stroke
Intracranial hemorrhage
Antibody therapy
Blood-brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823000762

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http://www.sciencedirect.com/science/article/pii/S1043661823000762

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