Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers
The in vivo investigation of kynurenic acid (KYNA) and its analogs is one of the recent exciting topics in pharmacology. In the current study we assessed the biological effects of these molecules on bdelloid rotifers (<i>Philodina acuticornis</i> and <i>Adineta vaga</i>) by m...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/11/2171 |
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| author | Zsolt Datki Zita Galik-Olah Zsuzsanna Bohar Denes Zadori Ferenc Fulop Istvan Szatmari Bence Galik Janos Kalman Laszlo Vecsei |
| author_facet | Zsolt Datki Zita Galik-Olah Zsuzsanna Bohar Denes Zadori Ferenc Fulop Istvan Szatmari Bence Galik Janos Kalman Laszlo Vecsei |
| author_sort | Zsolt Datki |
| collection | DOAJ |
| description | The in vivo investigation of kynurenic acid (KYNA) and its analogs is one of the recent exciting topics in pharmacology. In the current study we assessed the biological effects of these molecules on bdelloid rotifers (<i>Philodina acuticornis</i> and <i>Adineta vaga</i>) by monitoring changes in their survival and phenotypical characteristics. In addition to longitudinal (slowly changing) markers (survival, number of rotifers alive and body size index), some dynamic (quickly responding) ones (cellular reduction capacity and mastax contraction frequency) were measured as well. KYNA and its analogs increased longevity, reproduction and growth, whereas reduction capacity and energy-dependent muscular activity decreased conversely. We found that spermidine, a calorie restriction mimetic, exerted similar changes in the applied micro-invertebrates. This characterized systemic profile evoked by the above-mentioned compounds was named beneficial physiologic attenuation. In reference experiments, using a stimulator (cyclic adenosine monophosphate) and a toxin (sodium azide), all parameters changed in the same direction (positively or negatively, respectively), as expected. The currently described adaptive phenomenon in bdelloid rotifers may provide holistic perspectives in translational research. |
| first_indexed | 2024-12-10T08:50:56Z |
| format | Article |
| id | doaj.art-bad806cd7be44186ac1c48c7a25f70e9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T08:50:56Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bad806cd7be44186ac1c48c7a25f70e92022-12-22T01:55:35ZengMDPI AGMolecules1420-30492019-06-012411217110.3390/molecules24112171molecules24112171Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid RotifersZsolt Datki0Zita Galik-Olah1Zsuzsanna Bohar2Denes Zadori3Ferenc Fulop4Istvan Szatmari5Bence Galik6Janos Kalman7Laszlo Vecsei8Department of Psychiatry, Faculty of Medicine, University of Szeged, Kalvaria sgt. 57, H-6725 Szeged, HungaryDepartment of Psychiatry, Faculty of Medicine, University of Szeged, Kalvaria sgt. 57, H-6725 Szeged, HungaryMTA-SZTE Neuroscience Research Group, Semmelweis u. 6, H-6725 Szeged, HungaryDepartment of Neurology, Interdisciplinary Excellence Centre, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725 Szeged, HungaryInstitute of Pharmaceutical Chemistry, Interdisciplinary Excellence Centre, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryInstitute of Pharmaceutical Chemistry, Interdisciplinary Excellence Centre, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, HungaryDepartment of Clinical Molecular Biology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Psychiatry, Faculty of Medicine, University of Szeged, Kalvaria sgt. 57, H-6725 Szeged, HungaryMTA-SZTE Neuroscience Research Group, Semmelweis u. 6, H-6725 Szeged, HungaryThe in vivo investigation of kynurenic acid (KYNA) and its analogs is one of the recent exciting topics in pharmacology. In the current study we assessed the biological effects of these molecules on bdelloid rotifers (<i>Philodina acuticornis</i> and <i>Adineta vaga</i>) by monitoring changes in their survival and phenotypical characteristics. In addition to longitudinal (slowly changing) markers (survival, number of rotifers alive and body size index), some dynamic (quickly responding) ones (cellular reduction capacity and mastax contraction frequency) were measured as well. KYNA and its analogs increased longevity, reproduction and growth, whereas reduction capacity and energy-dependent muscular activity decreased conversely. We found that spermidine, a calorie restriction mimetic, exerted similar changes in the applied micro-invertebrates. This characterized systemic profile evoked by the above-mentioned compounds was named beneficial physiologic attenuation. In reference experiments, using a stimulator (cyclic adenosine monophosphate) and a toxin (sodium azide), all parameters changed in the same direction (positively or negatively, respectively), as expected. The currently described adaptive phenomenon in bdelloid rotifers may provide holistic perspectives in translational research.https://www.mdpi.com/1420-3049/24/11/2171kynurenic acidmetabolismphysiologybdelloid rotifersurvivalmastax |
| spellingShingle | Zsolt Datki Zita Galik-Olah Zsuzsanna Bohar Denes Zadori Ferenc Fulop Istvan Szatmari Bence Galik Janos Kalman Laszlo Vecsei Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers Molecules kynurenic acid metabolism physiology bdelloid rotifer survival mastax |
| title | Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers |
| title_full | Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers |
| title_fullStr | Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers |
| title_full_unstemmed | Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers |
| title_short | Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers |
| title_sort | kynurenic acid and its analogs are beneficial physiologic attenuators in bdelloid rotifers |
| topic | kynurenic acid metabolism physiology bdelloid rotifer survival mastax |
| url | https://www.mdpi.com/1420-3049/24/11/2171 |
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