The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder
Aims: To evaluate the impact of a histologically inverted pattern on recurrence in patients with newly diagnosed non-invasive, low-grade papillary urothelial carcinoma of the urinary bladder. Methods: A total of 81 patients with primary bladder non-invasive, low-grade papillary urothelial carcinoma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-10-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=1760 |
| _version_ | 1797908637721559040 |
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| author | Sehbal Arslankoz İbrahim Kulaç Dilek Ertoy Baydar |
| author_facet | Sehbal Arslankoz İbrahim Kulaç Dilek Ertoy Baydar |
| author_sort | Sehbal Arslankoz |
| collection | DOAJ |
| description | Aims: To evaluate the impact of a histologically inverted pattern on recurrence in patients with newly diagnosed non-invasive, low-grade papillary urothelial carcinoma of the urinary bladder.
Methods: A total of 81 patients with primary bladder non-invasive, low-grade papillary urothelial carcinoma diagnosed in a single tertiary-care centre who had at least 1-year follow-up after an initial resection were included. All slides from each case were reviewed to determine the growth pattern (exophytic versus endophytic, i.e. inverted) and other histological parameters. Clinical data were retrieved from hospital records.
Results: Disease recurrence occurred in 41 (50.6%) patients. Cases with an inverted pattern showed a lower recurrence rate than those with pure exophytic tumours (37.5% versus 52.1%), a longer time to first recurrence (mean 34 versus 21.5 months) and fewer recurrence episodes (p=0.482, 0.564 and 0.051, respectively). All recurring inverted cases recurred only once during follow-up. No tumour with >80% inverted architecture recurred.
Conclusion: Our results suggest that non-invasive, low-grade papillary urothelial carcinoma of the bladder tends to have a better outcome in terms of disease recurrence if it shows an inverted growth pattern. To indicate the presence and percentage of the inverted pattern in low-grade urothelial carcinomas in the pathology report might be considered as an adjunct to help long-term patient management |
| first_indexed | 2024-04-10T10:55:38Z |
| format | Article |
| id | doaj.art-bad9621a4760482fbe0da5943e5501ef |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T10:55:38Z |
| publishDate | 2017-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-bad9621a4760482fbe0da5943e5501ef2023-02-15T16:19:59ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312017-10-0134546446810.4274/balkanmedj.2017.0081The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of BladderSehbal Arslankoz0İbrahim Kulaç1Dilek Ertoy Baydar2Department of Pathology, Hacettepe University School of Medicine, Ankara, TurkeyClinic of Pathology, Mardin State Hospital, Mardin, TurkeyDepartment of Pathology, Hacettepe University School of Medicine, Ankara, TurkeyAims: To evaluate the impact of a histologically inverted pattern on recurrence in patients with newly diagnosed non-invasive, low-grade papillary urothelial carcinoma of the urinary bladder. Methods: A total of 81 patients with primary bladder non-invasive, low-grade papillary urothelial carcinoma diagnosed in a single tertiary-care centre who had at least 1-year follow-up after an initial resection were included. All slides from each case were reviewed to determine the growth pattern (exophytic versus endophytic, i.e. inverted) and other histological parameters. Clinical data were retrieved from hospital records. Results: Disease recurrence occurred in 41 (50.6%) patients. Cases with an inverted pattern showed a lower recurrence rate than those with pure exophytic tumours (37.5% versus 52.1%), a longer time to first recurrence (mean 34 versus 21.5 months) and fewer recurrence episodes (p=0.482, 0.564 and 0.051, respectively). All recurring inverted cases recurred only once during follow-up. No tumour with >80% inverted architecture recurred. Conclusion: Our results suggest that non-invasive, low-grade papillary urothelial carcinoma of the bladder tends to have a better outcome in terms of disease recurrence if it shows an inverted growth pattern. To indicate the presence and percentage of the inverted pattern in low-grade urothelial carcinomas in the pathology report might be considered as an adjunct to help long-term patient managementhttp://balkanmedicaljournal.org/text.php?lang=en&id=1760Urinary bladderurothelial carcinomanon-invasive low gradeinverted |
| spellingShingle | Sehbal Arslankoz İbrahim Kulaç Dilek Ertoy Baydar The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder Balkan Medical Journal Urinary bladder urothelial carcinoma non-invasive low grade inverted |
| title | The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder |
| title_full | The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder |
| title_fullStr | The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder |
| title_full_unstemmed | The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder |
| title_short | The Influence of Inverted Growth Pattern on Recurrence for Patients with Non-Invasive Low Grade Papillary Urothelial Carcinoma of Bladder |
| title_sort | influence of inverted growth pattern on recurrence for patients with non invasive low grade papillary urothelial carcinoma of bladder |
| topic | Urinary bladder urothelial carcinoma non-invasive low grade inverted |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=1760 |
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