Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs
Background: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common drug classes leading to toxicity. The aim of this study was to evaluate the demographic characteristics, clinical symptoms, and treatment outcome of patients with SSRI poisoning.Methods: In this retrospective cros...
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Isfahan University of Medical Sciences
2022-12-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | https://jims.mui.ac.ir/article_26266_c41fffd2de3c15fb2250d847dfe53beb.pdf |
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| author | Nastaran Eizadi-Mood Narges Khademi Shadi Haddad maryam Ghasemi aliabadi Parastoo Golshiri Rokhsareh Meamar |
| author_facet | Nastaran Eizadi-Mood Narges Khademi Shadi Haddad maryam Ghasemi aliabadi Parastoo Golshiri Rokhsareh Meamar |
| author_sort | Nastaran Eizadi-Mood |
| collection | DOAJ |
| description | Background: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common drug classes leading to toxicity. The aim of this study was to evaluate the demographic characteristics, clinical symptoms, and treatment outcome of patients with SSRI poisoning.Methods: In this retrospective cross-sectional study, demographic, toxicological and clinical data were analyzed from the data of patients poisoned with SSRIs in 2019 in the referral poisoning emergency center of Khorshid Hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran.Findings: Out of the 6631 poisoned emergency patients, 66 patients (1%) were hospitalized due to SSRI poisonings. The most common poisoning drug was citalopram (39.4%) followed by sertraline (37.9%). The mean age of patients was 25.9 years and most of them were women (90.9%) with intentional poisoning (78.8%). Nausea and vomiting (43.9%) were the most common clinical symptoms. 20 patients (30.3%) had sinus tachycardia, which was mostly related to sertraline (26.7%). Two patients (3%) had seizures with citalopram and only one patient had serotonin toxicity following citalopram ingestion. The mean length of hospital stay was 0.56±1.54. None of the factors investigated was a good predictor for the duration of hospital stay duration.Conclusion: In this study, the most common SSRIs causing poisoning were citalopram, followed by sertraline. All patients were discharged with supportive measures and with complete recovery, but in order to evaluate the effects of poisoning of these drugs, there is a need for studies in longer periods of time and with larger sample size. |
| first_indexed | 2024-03-12T05:14:02Z |
| format | Article |
| id | doaj.art-badf1450154540b5b8f122e1fe53aa0e |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T05:14:02Z |
| publishDate | 2022-12-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-badf1450154540b5b8f122e1fe53aa0e2023-09-03T08:22:20ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2022-12-014069285786410.48305/jims.v40.i692.085726266Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor DrugsNastaran Eizadi-Mood0Narges Khademi1Shadi Haddad2maryam Ghasemi aliabadi3Parastoo Golshiri4Rokhsareh Meamar5Professor, Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranGeneral Physician, Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, IranGeneral Physician, Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, IranGeneral Physician, Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Community and Preventive Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, IranBackground: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common drug classes leading to toxicity. The aim of this study was to evaluate the demographic characteristics, clinical symptoms, and treatment outcome of patients with SSRI poisoning.Methods: In this retrospective cross-sectional study, demographic, toxicological and clinical data were analyzed from the data of patients poisoned with SSRIs in 2019 in the referral poisoning emergency center of Khorshid Hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran.Findings: Out of the 6631 poisoned emergency patients, 66 patients (1%) were hospitalized due to SSRI poisonings. The most common poisoning drug was citalopram (39.4%) followed by sertraline (37.9%). The mean age of patients was 25.9 years and most of them were women (90.9%) with intentional poisoning (78.8%). Nausea and vomiting (43.9%) were the most common clinical symptoms. 20 patients (30.3%) had sinus tachycardia, which was mostly related to sertraline (26.7%). Two patients (3%) had seizures with citalopram and only one patient had serotonin toxicity following citalopram ingestion. The mean length of hospital stay was 0.56±1.54. None of the factors investigated was a good predictor for the duration of hospital stay duration.Conclusion: In this study, the most common SSRIs causing poisoning were citalopram, followed by sertraline. All patients were discharged with supportive measures and with complete recovery, but in order to evaluate the effects of poisoning of these drugs, there is a need for studies in longer periods of time and with larger sample size.https://jims.mui.ac.ir/article_26266_c41fffd2de3c15fb2250d847dfe53beb.pdfssridemographypoisoningcritical care outcomesdrug-related side effects and adverse reactions |
| spellingShingle | Nastaran Eizadi-Mood Narges Khademi Shadi Haddad maryam Ghasemi aliabadi Parastoo Golshiri Rokhsareh Meamar Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs مجله دانشکده پزشکی اصفهان ssri demography poisoning critical care outcomes drug-related side effects and adverse reactions |
| title | Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs |
| title_full | Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs |
| title_fullStr | Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs |
| title_full_unstemmed | Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs |
| title_short | Demographic Factors, Clinical Manifestations and Treatment Outcomes in Patients Poisoned with Selective Serotonin Reuptake Inhibitor Drugs |
| title_sort | demographic factors clinical manifestations and treatment outcomes in patients poisoned with selective serotonin reuptake inhibitor drugs |
| topic | ssri demography poisoning critical care outcomes drug-related side effects and adverse reactions |
| url | https://jims.mui.ac.ir/article_26266_c41fffd2de3c15fb2250d847dfe53beb.pdf |
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