Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis
<p>Abstract</p> <p>Background</p> <p>Migraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
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| Series: | BMC Neurology |
| Online Access: | http://www.biomedcentral.com/1471-2377/11/66 |
| _version_ | 1818471743774261248 |
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| author | Mente Andrew Owen Mike Korszun Ania Jones Lisa Craddock Nick Cohen-Woods Sarah Gaysina Daria Samaan Zainab McGuffin Peter Farmer Anne |
| author_facet | Mente Andrew Owen Mike Korszun Ania Jones Lisa Craddock Nick Cohen-Woods Sarah Gaysina Daria Samaan Zainab McGuffin Peter Farmer Anne |
| author_sort | Mente Andrew |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Migraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of MTHFR with migraine has been inconclusive. We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date.</p> <p>Methods</p> <p>Individuals with migraine (n = 447) were selected from the Depression Case Control (DeCC) study to investigate the association between migraine and MTHFR C677T single nucleotide polymorphism (SNP) rs1801133 using an additive model compared to non-migraineurs adjusting for depression status. A meta-analysis was performed and included 15 studies of MTHFR and migraine.</p> <p>Results</p> <p>MTHFR C677T polymorphism was associated with migraine with aura (MA) (OR 1.31, 95% CI 1.01-1.70, p = 0.039) that remained significant after adjusting for age, sex and depression status. A meta-analysis of 15 case-control studies showed that T allele homozygosity is significantly associated with MA (OR = 1.42; 95% CI, 1.10-1.82) and total migraine (OR = 1.37; 95% CI, 1.07-1.76), but not migraine without aura (OR = 1.16; 95% CI, 0.36-3.76). In studies of non-Caucasian population, the TT genotype was associated with total migraine (OR= 3.46; 95% CI, 1.22-9.82), whereas in studies of Caucasians this variant was associated with MA only (OR = 1.28; 95% CI, 1.002-1.63).</p> <p>Conclusions</p> <p>MTHFR C677T is associated with MA in individuals selected for depression study. A meta-analysis of 15 studies supports this association and demonstrated effects across ethnic groups.</p> |
| first_indexed | 2024-04-14T03:56:33Z |
| format | Article |
| id | doaj.art-bae0c6efb98b495f9fb1894a44afae51 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-14T03:56:33Z |
| publishDate | 2011-06-01 |
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| series | BMC Neurology |
| spelling | doaj.art-bae0c6efb98b495f9fb1894a44afae512022-12-22T02:13:47ZengBMCBMC Neurology1471-23772011-06-011116610.1186/1471-2377-11-66Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysisMente AndrewOwen MikeKorszun AniaJones LisaCraddock NickCohen-Woods SarahGaysina DariaSamaan ZainabMcGuffin PeterFarmer Anne<p>Abstract</p> <p>Background</p> <p>Migraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of MTHFR with migraine has been inconclusive. We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date.</p> <p>Methods</p> <p>Individuals with migraine (n = 447) were selected from the Depression Case Control (DeCC) study to investigate the association between migraine and MTHFR C677T single nucleotide polymorphism (SNP) rs1801133 using an additive model compared to non-migraineurs adjusting for depression status. A meta-analysis was performed and included 15 studies of MTHFR and migraine.</p> <p>Results</p> <p>MTHFR C677T polymorphism was associated with migraine with aura (MA) (OR 1.31, 95% CI 1.01-1.70, p = 0.039) that remained significant after adjusting for age, sex and depression status. A meta-analysis of 15 case-control studies showed that T allele homozygosity is significantly associated with MA (OR = 1.42; 95% CI, 1.10-1.82) and total migraine (OR = 1.37; 95% CI, 1.07-1.76), but not migraine without aura (OR = 1.16; 95% CI, 0.36-3.76). In studies of non-Caucasian population, the TT genotype was associated with total migraine (OR= 3.46; 95% CI, 1.22-9.82), whereas in studies of Caucasians this variant was associated with MA only (OR = 1.28; 95% CI, 1.002-1.63).</p> <p>Conclusions</p> <p>MTHFR C677T is associated with MA in individuals selected for depression study. A meta-analysis of 15 studies supports this association and demonstrated effects across ethnic groups.</p>http://www.biomedcentral.com/1471-2377/11/66 |
| spellingShingle | Mente Andrew Owen Mike Korszun Ania Jones Lisa Craddock Nick Cohen-Woods Sarah Gaysina Daria Samaan Zainab McGuffin Peter Farmer Anne Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis BMC Neurology |
| title | Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis |
| title_full | Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis |
| title_fullStr | Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis |
| title_full_unstemmed | Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis |
| title_short | Methylenetetrahydrofolate Reductase Gene Variant (MTHFR C677T) and Migraine: A Case Control Study and Meta-analysis |
| title_sort | methylenetetrahydrofolate reductase gene variant mthfr c677t and migraine a case control study and meta analysis |
| url | http://www.biomedcentral.com/1471-2377/11/66 |
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