Intratumoral delivery of a novel oncolytic adenovirus encoding human antibody against PD-1 elicits enhanced antitumor efficacy

Intratumoral delivery of a novel oncolytic adenovirus encoding human antibody against PD-1 elicits enhanced antitumor efficacy

To date, diverse combination therapies with immune checkpoint inhibitors (ICIs), particularly oncolytic virotherapy, have demonstrated enhanced therapeutic outcomes in cancer treatment. However, high pre-existing immunity against the widely used adenovirus human serotype 5 (AdHu5) limits its extensi...

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Bibliographic Details
Main Authors: Ping Zhou, Xuchen Wang, Man Xing, Xi Yang, Mangteng Wu, Hongyang Shi, Caihong Zhu, Xiang Wang, Yingying Guo, Shubing Tang, Zhong Huang, Dongming Zhou
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
chimpanzee adenovirus
oncolytic virus
checkpoint inhibitors
PD-1
combination cancer therapy
alternative
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000596

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