Animal models of ovarian cancer
<p>Abstract</p> <p>Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells. However, the majority of ovarian cancers arise from the surface epithelium, a single layer of ce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-10-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.RBEj.com/content/1/1/67 |
| _version_ | 1811314291838550016 |
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| author | Shaw Tanya J Vanderhyden Barbara C Ethier Jean-François |
| author_facet | Shaw Tanya J Vanderhyden Barbara C Ethier Jean-François |
| author_sort | Shaw Tanya J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells. However, the majority of ovarian cancers arise from the surface epithelium, a single layer of cells that covers the surface of the ovary. The lack of a reliable and specific method for the early detection of epithelial ovarian cancer results in diagnosis occurring most commonly at late clinical stages, when treatment is less effective. In part, the deficiency in diagnostic tools is due to the lack of markers for the detection of preneoplastic or early neoplastic changes in the epithelial cells, which reflects our rather poor understanding of this process. Animal models which accurately represent the cellular and molecular changes associated with the initiation and progression of human ovarian cancer have significant potential to facilitate the development of better methods for the early detection and treatment of ovarian cancer. This review describes some of the experimental animal models of ovarian tumorigenesis that have been reported, including those involving specific reproductive factors and environmental toxins. Consideration has also been given to the recent progress in modeling ovarian cancer using genetically engineered mice.</p> |
| first_indexed | 2024-04-13T11:09:16Z |
| format | Article |
| id | doaj.art-bae6cbc3d225417eb036699eb00521cf |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-13T11:09:16Z |
| publishDate | 2003-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-bae6cbc3d225417eb036699eb00521cf2022-12-22T02:49:10ZengBMCReproductive Biology and Endocrinology1477-78272003-10-01116710.1186/1477-7827-1-67Animal models of ovarian cancerShaw Tanya JVanderhyden Barbara CEthier Jean-François<p>Abstract</p> <p>Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells. However, the majority of ovarian cancers arise from the surface epithelium, a single layer of cells that covers the surface of the ovary. The lack of a reliable and specific method for the early detection of epithelial ovarian cancer results in diagnosis occurring most commonly at late clinical stages, when treatment is less effective. In part, the deficiency in diagnostic tools is due to the lack of markers for the detection of preneoplastic or early neoplastic changes in the epithelial cells, which reflects our rather poor understanding of this process. Animal models which accurately represent the cellular and molecular changes associated with the initiation and progression of human ovarian cancer have significant potential to facilitate the development of better methods for the early detection and treatment of ovarian cancer. This review describes some of the experimental animal models of ovarian tumorigenesis that have been reported, including those involving specific reproductive factors and environmental toxins. Consideration has also been given to the recent progress in modeling ovarian cancer using genetically engineered mice.</p>http://www.RBEj.com/content/1/1/67 |
| spellingShingle | Shaw Tanya J Vanderhyden Barbara C Ethier Jean-François Animal models of ovarian cancer Reproductive Biology and Endocrinology |
| title | Animal models of ovarian cancer |
| title_full | Animal models of ovarian cancer |
| title_fullStr | Animal models of ovarian cancer |
| title_full_unstemmed | Animal models of ovarian cancer |
| title_short | Animal models of ovarian cancer |
| title_sort | animal models of ovarian cancer |
| url | http://www.RBEj.com/content/1/1/67 |
| work_keys_str_mv | AT shawtanyaj animalmodelsofovariancancer AT vanderhydenbarbarac animalmodelsofovariancancer AT ethierjeanfrancois animalmodelsofovariancancer |