Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
Abstract Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe3O4, the f...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-04-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-020-03309-w |
| _version_ | 1797762745517473792 |
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| author | Zhenhui Nie Ningbin Luo Junjie Liu Xinyi Zeng Yu Zhang Danke Su |
| author_facet | Zhenhui Nie Ningbin Luo Junjie Liu Xinyi Zeng Yu Zhang Danke Su |
| author_sort | Zhenhui Nie |
| collection | DOAJ |
| description | Abstract Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe3O4, the fluorescent dye Cy5.5, and the CO2 releasing donor (Na2CO3). The nanoparticles can continuously generate carbon dioxide (CO2) gas in acidic tumour tissue in the body, giving the tumour a strong echo signal under ultrasonic imaging. In addition, the nanoparticles confer excellent effects for MR and fluorescence imaging of the tumour tissue. The results indicate that this pH-responsive NP system provides good effects in MR/US/fluorescent imaging. This study provides a useful reference for multi-mode tumour imaging. |
| first_indexed | 2024-03-12T19:32:52Z |
| format | Article |
| id | doaj.art-bae78281d7584ec8ba5c2a68b2d6a99e |
| institution | Directory Open Access Journal |
| issn | 1556-276X |
| language | English |
| last_indexed | 2024-03-12T19:32:52Z |
| publishDate | 2020-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-bae78281d7584ec8ba5c2a68b2d6a99e2023-08-02T04:25:47ZengSpringerOpenNanoscale Research Letters1556-276X2020-04-0115111310.1186/s11671-020-03309-wMulti-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imagingZhenhui Nie0Ningbin Luo1Junjie Liu2Xinyi Zeng3Yu Zhang4Danke Su5Department of Radiology, Affiliated Tumour Hospital of Guangxi Medical UniversityDepartment of Radiology, Affiliated Tumour Hospital of Guangxi Medical UniversityDepartment of Medical Ultrasound, Affiliated Tumour Hospital of Guangxi Medical UniversityDepartment of Radiology, Affiliated Tumour Hospital of Guangxi Medical UniversityDepartment of Radiology, Affiliated Tumour Hospital of Guangxi Medical UniversityDepartment of Radiology, Affiliated Tumour Hospital of Guangxi Medical UniversityAbstract Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe3O4, the fluorescent dye Cy5.5, and the CO2 releasing donor (Na2CO3). The nanoparticles can continuously generate carbon dioxide (CO2) gas in acidic tumour tissue in the body, giving the tumour a strong echo signal under ultrasonic imaging. In addition, the nanoparticles confer excellent effects for MR and fluorescence imaging of the tumour tissue. The results indicate that this pH-responsive NP system provides good effects in MR/US/fluorescent imaging. This study provides a useful reference for multi-mode tumour imaging.http://link.springer.com/article/10.1186/s11671-020-03309-wUltrasoundGas-generating nanoparticleMulti-mode imagingTumour targetingContrast agent |
| spellingShingle | Zhenhui Nie Ningbin Luo Junjie Liu Xinyi Zeng Yu Zhang Danke Su Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging Nanoscale Research Letters Ultrasound Gas-generating nanoparticle Multi-mode imaging Tumour targeting Contrast agent |
| title | Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging |
| title_full | Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging |
| title_fullStr | Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging |
| title_full_unstemmed | Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging |
| title_short | Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging |
| title_sort | multi mode biodegradable tumour microenvironment sensitive nanoparticles for targeted breast cancer imaging |
| topic | Ultrasound Gas-generating nanoparticle Multi-mode imaging Tumour targeting Contrast agent |
| url | http://link.springer.com/article/10.1186/s11671-020-03309-w |
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