Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer
Olaparib is recently approved as an anti-tumor agent for several cancers, including castration-resistant prostate cancer, which inhibits poly (adenosine diphosphate-ribose) polymerase, a DNA repair factor. Since olaparib is a newly approved drug, there are few reports of skin disorders that may be t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-06-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/530981 |
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| author | Mana Sekine Hitoshi Terui Taku Fujimura Yoshihide Asano |
| author_facet | Mana Sekine Hitoshi Terui Taku Fujimura Yoshihide Asano |
| author_sort | Mana Sekine |
| collection | DOAJ |
| description | Olaparib is recently approved as an anti-tumor agent for several cancers, including castration-resistant prostate cancer, which inhibits poly (adenosine diphosphate-ribose) polymerase, a DNA repair factor. Since olaparib is a newly approved drug, there are few reports of skin disorders that may be triggered by olaparib administration. In this report, we present a case with an olaparib-induced drug eruption presenting multiple purpuras on the patient’s fingers and fingertips. The present case suggests that olaparib might induce purpura as nonallergic drug eruption. |
| first_indexed | 2024-03-13T02:31:27Z |
| format | Article |
| id | doaj.art-baea235b61f747a0823473110f7e1d87 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-13T02:31:27Z |
| publishDate | 2023-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-baea235b61f747a0823473110f7e1d872023-06-29T14:41:53ZengKarger PublishersCase Reports in Oncology1662-65752023-06-0116141942110.1159/000530981530981Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate CancerMana Sekine0Hitoshi Terui1https://orcid.org/0000-0002-7598-2833Taku Fujimura2Yoshihide Asano3https://orcid.org/0000-0001-5560-9778Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai, JapanOlaparib is recently approved as an anti-tumor agent for several cancers, including castration-resistant prostate cancer, which inhibits poly (adenosine diphosphate-ribose) polymerase, a DNA repair factor. Since olaparib is a newly approved drug, there are few reports of skin disorders that may be triggered by olaparib administration. In this report, we present a case with an olaparib-induced drug eruption presenting multiple purpuras on the patient’s fingers and fingertips. The present case suggests that olaparib might induce purpura as nonallergic drug eruption.https://beta.karger.com/Article/FullText/530981olaparibpurpuradrug eruptiondrug reactioncastration-resistant prostate cancer |
| spellingShingle | Mana Sekine Hitoshi Terui Taku Fujimura Yoshihide Asano Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer Case Reports in Oncology olaparib purpura drug eruption drug reaction castration-resistant prostate cancer |
| title | Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer |
| title_full | Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer |
| title_fullStr | Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer |
| title_full_unstemmed | Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer |
| title_short | Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer |
| title_sort | olaparib induced purpuric drug eruption in a patient with castration resistant prostate cancer |
| topic | olaparib purpura drug eruption drug reaction castration-resistant prostate cancer |
| url | https://beta.karger.com/Article/FullText/530981 |
| work_keys_str_mv | AT manasekine olaparibinducedpurpuricdrugeruptioninapatientwithcastrationresistantprostatecancer AT hitoshiterui olaparibinducedpurpuricdrugeruptioninapatientwithcastrationresistantprostatecancer AT takufujimura olaparibinducedpurpuricdrugeruptioninapatientwithcastrationresistantprostatecancer AT yoshihideasano olaparibinducedpurpuricdrugeruptioninapatientwithcastrationresistantprostatecancer |