High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role

High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role

Phosphoglycerate mutase (PGAM) is a glycolytic enzyme converting 3-phosphoglycerate to 2-phosphoglycerate, which in mammalian cells is expressed in two isoforms: brain (PGAM1) and muscle (PGAM2). Recently, it was shown that besides its enzymatic function, PGAM2 can be imported to the cell nucleus wh...

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Bibliographic Details
Main Authors: Janusz Wiśniewski, Jakub Barciszewski, Jakub Turlik, Karolina Baran, Przemysław Duda, Mariusz Jaskolski, Dariusz Rakus
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
phosphoglycerate mutase
protein structure
14-3-3
nucleolus
protein–protein interaction
mTOR
Online Access:https://www.mdpi.com/1422-0067/23/21/13198

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