iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine

iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine

Liver transplantation is the most common treatment for patients suffering from liver failure that is caused by congenital diseases, infectious agents, and environmental factors. Despite a high rate of patient survival following transplantation, organ availability remains the key limiting factor. As...

Full description

Bibliographic Details
Main Authors:	Cristina Olgasi, Alessia Cucci, Antonia Follenzi
Format:	Article
Language:	English
Published:	MDPI AG 2020-08-01
Series:	International Journal of Molecular Sciences
Subjects:	iPSCs hepatocytes endothelial cells cholangiocytes Kupffer cells liver disease
Online Access:	https://www.mdpi.com/1422-0067/21/17/6215

Similar Items

Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening
by: Mattia Pasqua, et al.
Published: (2021-07-01)

Cellular heterogeneity and plasticity during NAFLD progression
by: Hyun-Ju Park, et al.
Published: (2023-08-01)

Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models
by: Abida Islam Pranty, et al.
Published: (2022-08-01)

Integration of iPSC-Derived Microglia into Brain Organoids for Neurological Research
by: Muhammad Asif Mrza, et al.
Published: (2024-03-01)

Modeling brain macrophage biology and neurodegenerative diseases using human iPSC-derived neuroimmune organoids
by: Jonas Cerneckis, et al.
Published: (2023-06-01)

Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors
by: Blair K. Gage, et al.
Published: (2022-04-01)

iPSC for modeling neurodegenerative disorders
by: Valeria Valadez-Barba, et al.
Published: (2020-12-01)

iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial Hypercholesterolemia
by: Irina S. Zakharova, et al.
Published: (2024-01-01)

Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids
by: Guoqiang Sun, et al.
Published: (2020-04-01)

Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
by: Christiane Loerch, et al.
Published: (2024-04-01)

Human-Origin iPSC-Based Recellularization of Decellularized Whole Rat Livers
by: Aylin Acun, et al.
Published: (2022-05-01)

Low-Intensity Pulsed Ultrasound Promotes Osteogenic Potential of iPSC-Derived MSCs but Fails to Simplify the iPSC-EB-MSC Differentiation Process
by: Ziyi Hua, et al.
Published: (2022-05-01)

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures
by: Siiri Suominen, et al.
Published: (2023-09-01)

A Review of Prostate Organogenesis and a Role for iPSC-Derived Prostate Organoids to Study Prostate Development and Disease
by: Adriana Buskin, et al.
Published: (2021-12-01)

A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees
by: Michelle C Ward, et al.
Published: (2019-04-01)

Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids
by: Gianluca Costamagna, et al.
Published: (2021-03-01)

Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through
by: Amirah Syamimi Jusop, et al.
Published: (2023-08-01)

Generation of self-assembling cardiac organoids using hiPSC-derived cardiomyocytes
by: Karolina Künzel, et al.
Published: (2022-09-01)

An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells
by: Li-Jie Hsu, et al.
Published: (2021-09-01)

Generation and characterization of human-derived iPSC lines from one pair of dizygotic twins discordant for schizophrenia
by: Peiyan Ni, et al.
Published: (2022-04-01)

Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes
by: Harini V. Gudiseva, et al.
Published: (2021-12-01)

Clinical Potential of Cellular Material Sources in the Generation of iPSC-Based Products for the Regeneration of Articular Cartilage
by: Artem Eremeev, et al.
Published: (2023-09-01)

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
by: Maria G. Otero, et al.
Published: (2023-09-01)

Human fibroblasts facilitate the generation of iPSCs-derived mammary-like organoids
by: Xueqin Dai, et al.
Published: (2022-07-01)

Hepatic Models in Precision Medicine: An African Perspective on Pharmacovigilance
by: Tracey Hurrell, et al.
Published: (2022-04-01)

Liver aquaporins: Significance in canalicular and ductal bile formation
by: Raúl A. Marinelli, et al.
Published: (2004-10-01)

iPSC Preparation and Epigenetic Memory: Does the Tissue Origin Matter?
by: Giuseppe Scesa, et al.
Published: (2021-06-01)

Hypoimmunogenic Human Pluripotent Stem Cells as a Powerful Tool for Liver Regenerative Medicine
by: Piera Trionfini, et al.
Published: (2023-07-01)

Generation and proteome profiling of PBMC-originated, iPSC-derived lentoid bodies
by: Muhammad Ali, et al.
Published: (2020-07-01)

A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
by: Hiroko Shimada, et al.
Published: (2022-09-01)

Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential
by: Rosa A. van Amerongen, et al.
Published: (2023-03-01)

Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells
by: Takashi Satake, et al.
Published: (2022-07-01)

Liver Organoids: Updates on Disease Modeling and Biomedical Applications
by: Carmen Caiazza, et al.
Published: (2021-08-01)

An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation
by: Emma Poole, et al.
Published: (2019-10-01)

Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models
by: Sopak Supakul, et al.
Published: (2024-03-01)

Generation of two additional integration-free iPSC lines from related human donors
by: Anja Patricia Ramme, et al.
Published: (2021-05-01)

The endothelium, a key actor in organ development and hPSC-derived organoid vascularization
by: Alejandra Vargas-Valderrama, et al.
Published: (2020-05-01)

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs
by: Yi Yang, et al.
Published: (2018-01-01)

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age
by: Dominik Hanetseder, et al.
Published: (2023-08-01)

iPSCs are safe!
by: Hualong Yan, et al.
Published: (2017-05-01)