| Summary: | Prostate cancer (PC) is one of the prevalent tumors in men causing higher
mortality. Luteoloside has been discovered for suppressive role into the
progression of some cancers. However, the Luteoloside’s regulatory functions
regarding PC progression are not well understood. This study is thus designed to
investigate the Luteoloside impact on PC progression. In this work, it was
demonstrated that the PC cell proliferation was gradually inhibited with the
increasing Luteoloside dose (0, 20, 40, 80 µM). Luteoloside also enhanced
the PC cell apoptosis. It promoted the autophagy in PC through increasing microtubule-associated protein light chain
(LC) 3II/LC3I levels and decreasing p62 levels. Moreover, the Luteoloside reduced phosphorylated-protein kinase B (p-AKT)/AKT
and phosphorylated-mechanistic target of
rapamycin (p-mTOR)/mTOR levels, indicating
that it retarded the AKT/mTOR pathway. In conclusion, the Luteoloside inhibited PC cells growth
and promoted tumor cells autophagy through AKT/mTOR pathway. This discovery suggested the Luteoloside as
a potential drug in treating PC.
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