Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis
Schizophrenia (SZ) is associated with deficits in both temporal and salience processing. The underlying neurological dysfunctions in both processes, which are interrelated and share neuroanatomical bases, remain poorly understood. The principal objective of this study was to elucidate whether there...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844018332717 |
| _version_ | 1818111005331292160 |
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| author | Irene Alústiza María Sol Garcés Aleix Solanes Javier Goena Marta Ortuño Patricio Molero Joaquim Radua Felipe Ortuño |
| author_facet | Irene Alústiza María Sol Garcés Aleix Solanes Javier Goena Marta Ortuño Patricio Molero Joaquim Radua Felipe Ortuño |
| author_sort | Irene Alústiza |
| collection | DOAJ |
| description | Schizophrenia (SZ) is associated with deficits in both temporal and salience processing. The underlying neurological dysfunctions in both processes, which are interrelated and share neuroanatomical bases, remain poorly understood. The principal objective of this study was to elucidate whether there are any brain regions that show abnormal response during timing and oddball tasks in patients with SZ. To this end, we conducted a signed differential mapping (SDM) meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing abnormal responses elicited by tasks based on the oddball paradigm in patients with SZ. We conducted a similar SDM meta-analysis of neuroimaging studies of timing tasks in SZ. Finally, we undertook a multimodal meta-analysis to detect the common findings of the two previous meta-analyses. We found that SZ patients showed hypoactivation in cortical and subcortical areas related to timing. The dysfunction observed during timing tasks partially coincided with deficiencies in change-detection functions (particularly in the case of preattentional processing in the mismatch negativity response). We hypothesize that a dysfunctional timing/change detection network underlies the cognitive impairment observed in SZ. |
| first_indexed | 2024-12-11T02:56:10Z |
| format | Article |
| id | doaj.art-baec4e6ca67046368a4d03ad23fd1c8d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-11T02:56:10Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-baec4e6ca67046368a4d03ad23fd1c8d2022-12-22T01:23:09ZengElsevierHeliyon2405-84402018-12-01412e01004Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysisIrene Alústiza0María Sol Garcés1Aleix Solanes2Javier Goena3Marta Ortuño4Patricio Molero5Joaquim Radua6Felipe Ortuño7Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain; Corresponding author.Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, SpainInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain; FIDMAG Germanes Hospitalaries, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Saint Boi de Llobregat, Barcelona, SpainDepartment of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, SpainDepartment of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, SpainDepartment of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, SpainEarly Psychosis: Interventions & Clinical-detection (EPIC) Laboratory, King's College London, Institute of Psychiatry Psychology and Neuroscience, London, United Kingdom; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain; FIDMAG Germanes Hospitalaries, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Saint Boi de Llobregat, Barcelona, SpainDepartment of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, SpainSchizophrenia (SZ) is associated with deficits in both temporal and salience processing. The underlying neurological dysfunctions in both processes, which are interrelated and share neuroanatomical bases, remain poorly understood. The principal objective of this study was to elucidate whether there are any brain regions that show abnormal response during timing and oddball tasks in patients with SZ. To this end, we conducted a signed differential mapping (SDM) meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing abnormal responses elicited by tasks based on the oddball paradigm in patients with SZ. We conducted a similar SDM meta-analysis of neuroimaging studies of timing tasks in SZ. Finally, we undertook a multimodal meta-analysis to detect the common findings of the two previous meta-analyses. We found that SZ patients showed hypoactivation in cortical and subcortical areas related to timing. The dysfunction observed during timing tasks partially coincided with deficiencies in change-detection functions (particularly in the case of preattentional processing in the mismatch negativity response). We hypothesize that a dysfunctional timing/change detection network underlies the cognitive impairment observed in SZ.http://www.sciencedirect.com/science/article/pii/S2405844018332717Clinical psychologyPsychiatryNeuroscience |
| spellingShingle | Irene Alústiza María Sol Garcés Aleix Solanes Javier Goena Marta Ortuño Patricio Molero Joaquim Radua Felipe Ortuño Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis Heliyon Clinical psychology Psychiatry Neuroscience |
| title | Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis |
| title_full | Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis |
| title_fullStr | Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis |
| title_full_unstemmed | Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis |
| title_short | Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis |
| title_sort | aberrant timing and oddball detection in schizophrenia findings from a signed differential mapping meta analysis |
| topic | Clinical psychology Psychiatry Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2405844018332717 |
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