Receptors and Channels Associated with Alcohol Use: Contributions from
Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns of alcohol use. At the core of AUD’s behavioral manifestations are the profound structural, physiological, cellular, and molecular effects of alcohol on the brain. While the field has made considerable progr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-03-01
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| Series: | Neuroscience Insights |
| Online Access: | https://doi.org/10.1177/26331055211007441 |
| _version_ | 1819293502033362944 |
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| author | Kristin M Scaplen Emily Petruccelli |
| author_facet | Kristin M Scaplen Emily Petruccelli |
| author_sort | Kristin M Scaplen |
| collection | DOAJ |
| description | Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns of alcohol use. At the core of AUD’s behavioral manifestations are the profound structural, physiological, cellular, and molecular effects of alcohol on the brain. While the field has made considerable progress in understanding the neuromolecular targets of alcohol we still lack a comprehensive understanding of alcohol’s actions and effective treatment strategies. Drosophila melanogaster is a powerful model for investigating the neuromolecular targets of alcohol because flies model many of the core behavioral elements of AUD and offer a rich genetic toolkit to precisely reveal the in vivo molecular actions of alcohol. In this review, we focus on receptors and channels that are often targeted by alcohol within the brain. We discuss the general roles of these proteins, their role in alcohol-associated behaviors across species, and propose ways in which Drosophila models can help advance the field. |
| first_indexed | 2024-12-24T04:11:26Z |
| format | Article |
| id | doaj.art-baec944c8c5945b7bb34ccb41250f94c |
| institution | Directory Open Access Journal |
| issn | 2633-1055 |
| language | English |
| last_indexed | 2024-12-24T04:11:26Z |
| publishDate | 2021-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Neuroscience Insights |
| spelling | doaj.art-baec944c8c5945b7bb34ccb41250f94c2022-12-21T17:16:04ZengSAGE PublishingNeuroscience Insights2633-10552021-03-011610.1177/26331055211007441Receptors and Channels Associated with Alcohol Use: Contributions fromKristin M Scaplen0Emily Petruccelli1Department of Neuroscience, Brown University, Providence, RI, USADepartment of Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, IL, USAAlcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns of alcohol use. At the core of AUD’s behavioral manifestations are the profound structural, physiological, cellular, and molecular effects of alcohol on the brain. While the field has made considerable progress in understanding the neuromolecular targets of alcohol we still lack a comprehensive understanding of alcohol’s actions and effective treatment strategies. Drosophila melanogaster is a powerful model for investigating the neuromolecular targets of alcohol because flies model many of the core behavioral elements of AUD and offer a rich genetic toolkit to precisely reveal the in vivo molecular actions of alcohol. In this review, we focus on receptors and channels that are often targeted by alcohol within the brain. We discuss the general roles of these proteins, their role in alcohol-associated behaviors across species, and propose ways in which Drosophila models can help advance the field.https://doi.org/10.1177/26331055211007441 |
| spellingShingle | Kristin M Scaplen Emily Petruccelli Receptors and Channels Associated with Alcohol Use: Contributions from Neuroscience Insights |
| title | Receptors and Channels Associated with Alcohol Use: Contributions from |
| title_full | Receptors and Channels Associated with Alcohol Use: Contributions from |
| title_fullStr | Receptors and Channels Associated with Alcohol Use: Contributions from |
| title_full_unstemmed | Receptors and Channels Associated with Alcohol Use: Contributions from |
| title_short | Receptors and Channels Associated with Alcohol Use: Contributions from |
| title_sort | receptors and channels associated with alcohol use contributions from |
| url | https://doi.org/10.1177/26331055211007441 |
| work_keys_str_mv | AT kristinmscaplen receptorsandchannelsassociatedwithalcoholusecontributionsfrom AT emilypetruccelli receptorsandchannelsassociatedwithalcoholusecontributionsfrom |