Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol
Phytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds can be generally divided into two classes: psychoactive and non-psychoactive. Those which do not impart psychoactivity are assumed to predominantly function...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1066455/full |
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| author | Mohammad-Reza Ghovanloo Sulayman D. Dib-Hajj Samuel J. Goodchild Peter C. Ruben Stephen G. Waxman |
| author_facet | Mohammad-Reza Ghovanloo Sulayman D. Dib-Hajj Samuel J. Goodchild Peter C. Ruben Stephen G. Waxman |
| author_sort | Mohammad-Reza Ghovanloo |
| collection | DOAJ |
| description | Phytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds can be generally divided into two classes: psychoactive and non-psychoactive. Those which do not impart psychoactivity are assumed to predominantly function via endocannabinoid receptor (CB) -independent pathways and molecular targets, including other receptors and ion channels. Among these targets, the voltage-gated sodium (Nav) channels are particularly interesting due to their well-established role in electrical signalling in the nervous system. The interactions between the main non-psychoactive phytocannabinoid, cannabidiol (CBD), and Nav channels were studied in detail. In addition to CBD, cannabigerol (CBG), is another non-psychoactive molecule implicated as a potential therapeutic for several conditions, including pain via interactions with Nav channels. In this mini review, we provide an update on the interactions of Nav channels with CBD and CBG. |
| first_indexed | 2024-04-13T21:50:24Z |
| format | Article |
| id | doaj.art-baedbfaa8dce47ffb3e44ca8a92a4318 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T21:50:24Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-baedbfaa8dce47ffb3e44ca8a92a43182022-12-22T02:28:27ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.10664551066455Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerolMohammad-Reza Ghovanloo0Sulayman D. Dib-Hajj1Samuel J. Goodchild2Peter C. Ruben3Stephen G. Waxman4Department of Neurology, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Neurology, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, CanadaDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaDepartment of Neurology, Yale University School of Medicine, New Haven, CT, United StatesPhytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds can be generally divided into two classes: psychoactive and non-psychoactive. Those which do not impart psychoactivity are assumed to predominantly function via endocannabinoid receptor (CB) -independent pathways and molecular targets, including other receptors and ion channels. Among these targets, the voltage-gated sodium (Nav) channels are particularly interesting due to their well-established role in electrical signalling in the nervous system. The interactions between the main non-psychoactive phytocannabinoid, cannabidiol (CBD), and Nav channels were studied in detail. In addition to CBD, cannabigerol (CBG), is another non-psychoactive molecule implicated as a potential therapeutic for several conditions, including pain via interactions with Nav channels. In this mini review, we provide an update on the interactions of Nav channels with CBD and CBG.https://www.frontiersin.org/articles/10.3389/fphys.2022.1066455/fullcannabidiol (CBD)cannabigerol (CBG)voltage-gated sodium (Nav) channelsexcitabilitypharmacology |
| spellingShingle | Mohammad-Reza Ghovanloo Sulayman D. Dib-Hajj Samuel J. Goodchild Peter C. Ruben Stephen G. Waxman Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol Frontiers in Physiology cannabidiol (CBD) cannabigerol (CBG) voltage-gated sodium (Nav) channels excitability pharmacology |
| title | Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol |
| title_full | Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol |
| title_fullStr | Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol |
| title_full_unstemmed | Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol |
| title_short | Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol |
| title_sort | non psychotropic phytocannabinoid interactions with voltage gated sodium channels an update on cannabidiol and cannabigerol |
| topic | cannabidiol (CBD) cannabigerol (CBG) voltage-gated sodium (Nav) channels excitability pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1066455/full |
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