Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions
Nash et al. develop and characterise multilobulated 3D chicken enteroids from intestinal embryonic villi and adult crypts, which constitute an accessible model of the chicken intestine. This model enables manipulations, such as viral infection, to be performed without the need for micro-injection, t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01901-z |
| _version_ | 1818430740109459456 |
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| author | Tessa J. Nash Katrina M. Morris Neil A. Mabbott Lonneke Vervelde |
| author_facet | Tessa J. Nash Katrina M. Morris Neil A. Mabbott Lonneke Vervelde |
| author_sort | Tessa J. Nash |
| collection | DOAJ |
| description | Nash et al. develop and characterise multilobulated 3D chicken enteroids from intestinal embryonic villi and adult crypts, which constitute an accessible model of the chicken intestine. This model enables manipulations, such as viral infection, to be performed without the need for micro-injection, thus opening up more opportunities to explore epithelial and leukocyte interactions and responses in host–pathogen, food science and pharmaceutical research. |
| first_indexed | 2024-12-14T15:38:12Z |
| format | Article |
| id | doaj.art-baf12b80ee7b4780a418e0eb7d08e8a9 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T15:38:12Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-baf12b80ee7b4780a418e0eb7d08e8a92022-12-21T22:55:40ZengNature PortfolioCommunications Biology2399-36422021-03-014111510.1038/s42003-021-01901-zInside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactionsTessa J. Nash0Katrina M. Morris1Neil A. Mabbott2Lonneke Vervelde3Division of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghDivision of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghDivision of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghDivision of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of EdinburghNash et al. develop and characterise multilobulated 3D chicken enteroids from intestinal embryonic villi and adult crypts, which constitute an accessible model of the chicken intestine. This model enables manipulations, such as viral infection, to be performed without the need for micro-injection, thus opening up more opportunities to explore epithelial and leukocyte interactions and responses in host–pathogen, food science and pharmaceutical research.https://doi.org/10.1038/s42003-021-01901-z |
| spellingShingle | Tessa J. Nash Katrina M. Morris Neil A. Mabbott Lonneke Vervelde Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions Communications Biology |
| title | Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions |
| title_full | Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions |
| title_fullStr | Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions |
| title_full_unstemmed | Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions |
| title_short | Inside-out chicken enteroids with leukocyte component as a model to study host–pathogen interactions |
| title_sort | inside out chicken enteroids with leukocyte component as a model to study host pathogen interactions |
| url | https://doi.org/10.1038/s42003-021-01901-z |
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