Axonal Stimulations With a Higher Frequency Generate More Randomness in Neuronal Firing Rather Than Increase Firing Rates in Rat Hippocampus

Axonal Stimulations With a Higher Frequency Generate More Randomness in Neuronal Firing Rather Than Increase Firing Rates in Rat Hippocampus

Deep brain stimulation (DBS) has been used for treating many brain disorders. Clinical applications of DBS commonly require high-frequency stimulations (HFS, ∼100 Hz) of electrical pulses to obtain therapeutic efficacy. It is not clear whether the electrical energy of HFS functions other than genera...

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Bibliographic Details
Main Authors: Zhaoxiang Wang, Zhouyan Feng, Xuefeng Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neuroscience
Subjects:
high frequency stimulation
unit spikes
firing rate
randomness
desynchronization
electrical energy
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00783/full

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