Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma
Objective To analyze the safety and efficacy of pemetrexed-based chemotherapy on patients with mid-elderly non-Hodgkin's lymphoma. Methods We retrospectively reviewed the clinical data of patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy regimen from November...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2020-02-01
|
| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.1003.htm |
| _version_ | 1828388705873690624 |
|---|---|
| author | WEN Tingyu GUI Lin JIN Jun ZHANG Wei WANG Ting SHI Yuankai LIU Peng |
| author_facet | WEN Tingyu GUI Lin JIN Jun ZHANG Wei WANG Ting SHI Yuankai LIU Peng |
| author_sort | WEN Tingyu |
| collection | DOAJ |
| description | Objective To analyze the safety and efficacy of pemetrexed-based chemotherapy on patients with mid-elderly non-Hodgkin's lymphoma. Methods We retrospectively reviewed the clinical data of patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy regimen from November 2016 to October 2018 in the Cancer Hospital of Chinese Academy of Medical Sciences, and systematically reviewed the relevant literatures. Results We enrolled 10 patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy: 7 cases of diffuse large B-cell lymphoma, 2 cases of angioimmunoblastic T cell lymphoma and one case of extranodal NK/T cell lymphoma. After tumor recurrence or progression, these patients were treated with pemetrexed-based chemotherapy. Four cases of diffuse large B-cell lymphoma reached partial remission and three cases progressed. The main adverse events were low grade myelosuppression and gastrointestinal reactions. Conclusion Pemetrexed-based chemotherapy regimen may have certain effectiveness and safety on the patients with diffuse large B-cell lymphoma, especially primary central nervous system lymphoma. |
| first_indexed | 2024-12-10T06:17:22Z |
| format | Article |
| id | doaj.art-baf4b651f4a84cb8a34e26854fa9e272 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-10T06:17:22Z |
| publishDate | 2020-02-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-baf4b651f4a84cb8a34e26854fa9e2722022-12-22T01:59:25ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782020-02-0147211912310.3971/j.issn.1000-8578.2020.19.10038578.2020.19.1003Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's LymphomaWEN Tingyu0GUI Lin1JIN Jun2ZHANG Wei3WANG Ting4SHI Yuankai5LIU Peng6Department of Medical Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, ChinaDepartment of Medical Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, ChinaDepartment of Internal Medicine, Sanhuan Cancer Hospital, Beijing 100021, ChinaDepartment of Internal Medicine, Sanhuan Cancer Hospital, Beijing 100021, ChinaDepartment of Internal Medicine, Sanhuan Cancer Hospital, Beijing 100021, ChinaDepartment of Medical Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, ChinaDepartment of Medical Oncology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, ChinaObjective To analyze the safety and efficacy of pemetrexed-based chemotherapy on patients with mid-elderly non-Hodgkin's lymphoma. Methods We retrospectively reviewed the clinical data of patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy regimen from November 2016 to October 2018 in the Cancer Hospital of Chinese Academy of Medical Sciences, and systematically reviewed the relevant literatures. Results We enrolled 10 patients with non-Hodgkin's lymphoma treated with pemetrexed-based chemotherapy: 7 cases of diffuse large B-cell lymphoma, 2 cases of angioimmunoblastic T cell lymphoma and one case of extranodal NK/T cell lymphoma. After tumor recurrence or progression, these patients were treated with pemetrexed-based chemotherapy. Four cases of diffuse large B-cell lymphoma reached partial remission and three cases progressed. The main adverse events were low grade myelosuppression and gastrointestinal reactions. Conclusion Pemetrexed-based chemotherapy regimen may have certain effectiveness and safety on the patients with diffuse large B-cell lymphoma, especially primary central nervous system lymphoma.http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.1003.htmnon-hodgkin's lymphomadiffuse large b-cell lymphomapemetrexedchemotherapy |
| spellingShingle | WEN Tingyu GUI Lin JIN Jun ZHANG Wei WANG Ting SHI Yuankai LIU Peng Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma Zhongliu Fangzhi Yanjiu non-hodgkin's lymphoma diffuse large b-cell lymphoma pemetrexed chemotherapy |
| title | Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma |
| title_full | Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma |
| title_fullStr | Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma |
| title_full_unstemmed | Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma |
| title_short | Retrospective Analysis of Pemetrexed-based Chemotherapy Regimens on Mid-elderly Non-Hodgkin's Lymphoma |
| title_sort | retrospective analysis of pemetrexed based chemotherapy regimens on mid elderly non hodgkin s lymphoma |
| topic | non-hodgkin's lymphoma diffuse large b-cell lymphoma pemetrexed chemotherapy |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.1003.htm |
| work_keys_str_mv | AT wentingyu retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma AT guilin retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma AT jinjun retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma AT zhangwei retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma AT wangting retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma AT shiyuankai retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma AT liupeng retrospectiveanalysisofpemetrexedbasedchemotherapyregimensonmidelderlynonhodgkinslymphoma |