Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis
Tumor recurrence after surgical resection is associated with a poor clinical outcome. Here the authors design a manganese dioxide-based nanosystem to increase response to radio-immunotherapy by relieving tumor hypoxia and targeting myeloid cells, showing reduced post-surgical cancer recurrence and m...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30543-w |
| _version_ | 1811248822328754176 |
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| author | Xin Guan Liping Sun Yuting Shen Fengshan Jin Xiaowan Bo Chunyan Zhu Xiaoxia Han Xiaolong Li Yu Chen Huixiong Xu Wenwen Yue |
| author_facet | Xin Guan Liping Sun Yuting Shen Fengshan Jin Xiaowan Bo Chunyan Zhu Xiaoxia Han Xiaolong Li Yu Chen Huixiong Xu Wenwen Yue |
| author_sort | Xin Guan |
| collection | DOAJ |
| description | Tumor recurrence after surgical resection is associated with a poor clinical outcome. Here the authors design a manganese dioxide-based nanosystem to increase response to radio-immunotherapy by relieving tumor hypoxia and targeting myeloid cells, showing reduced post-surgical cancer recurrence and metastasis. |
| first_indexed | 2024-04-12T15:34:52Z |
| format | Article |
| id | doaj.art-baf5f14a5dbb41c780b94b2ea3f9c99a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:34:52Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-baf5f14a5dbb41c780b94b2ea3f9c99a2022-12-22T03:26:59ZengNature PortfolioNature Communications2041-17232022-05-0113111710.1038/s41467-022-30543-wNanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasisXin Guan0Liping Sun1Yuting Shen2Fengshan Jin3Xiaowan Bo4Chunyan Zhu5Xiaoxia Han6Xiaolong Li7Yu Chen8Huixiong Xu9Wenwen Yue10Department of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityMaterdicine Lab, School of Life Sciences, Shanghai UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityDepartment of Medical Ultrasound and Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People’s Hospital, School of Medicine, Tongji UniversityTumor recurrence after surgical resection is associated with a poor clinical outcome. Here the authors design a manganese dioxide-based nanosystem to increase response to radio-immunotherapy by relieving tumor hypoxia and targeting myeloid cells, showing reduced post-surgical cancer recurrence and metastasis.https://doi.org/10.1038/s41467-022-30543-w |
| spellingShingle | Xin Guan Liping Sun Yuting Shen Fengshan Jin Xiaowan Bo Chunyan Zhu Xiaoxia Han Xiaolong Li Yu Chen Huixiong Xu Wenwen Yue Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis Nature Communications |
| title | Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis |
| title_full | Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis |
| title_fullStr | Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis |
| title_full_unstemmed | Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis |
| title_short | Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis |
| title_sort | nanoparticle enhanced radiotherapy synergizes with pd l1 blockade to limit post surgical cancer recurrence and metastasis |
| url | https://doi.org/10.1038/s41467-022-30543-w |
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