Individual differences in rate of acquiring stable neural representations of tasks in fMRI.
Task-related functional magnetic resonance imaging (fMRI) is a widely-used tool for studying the neural processing correlates of human behavior in both healthy and clinical populations. There is growing interest in mapping individual differences in fMRI task behavior and neural responses. By utilizi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6261022?pdf=render |
| _version_ | 1818314315866832896 |
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| author | Ming-Hua Chung Bradford Martins Anthony Privratsky G Andrew James Clint D Kilts Keith A Bush |
| author_facet | Ming-Hua Chung Bradford Martins Anthony Privratsky G Andrew James Clint D Kilts Keith A Bush |
| author_sort | Ming-Hua Chung |
| collection | DOAJ |
| description | Task-related functional magnetic resonance imaging (fMRI) is a widely-used tool for studying the neural processing correlates of human behavior in both healthy and clinical populations. There is growing interest in mapping individual differences in fMRI task behavior and neural responses. By utilizing neuroadaptive task designs accounting for such individual differences, task durations can be personalized to potentially optimize neuroimaging study outcomes (e.g., classification of task-related brain states). To test this hypothesis, we first retrospectively tracked the volume-by-volume changes of beta weights generated from general linear models (GLM) for 67 adult subjects performing a stop-signal task (SST). We then modeled the convergence of the volume-by-volume changes of beta weights according to their exponential decay (ED) in units of half-life. Our results showed significant differences in beta weight convergence estimates of optimal stopping times (OSTs) between go following successful stop trials and failed stop trials for both cocaine dependent (CD) and control group (Con), and between go following successful stop trials and go following failed stop trials for Con group. Further, we implemented support vector machine (SVM) classification for 67 CD/Con labeled subjects and compared the classification accuracies of fMRI-based features derived from (1) the full fMRI task versus (2) the fMRI task truncated to multiples of the unit of half-life. Among the computed binary classification accuracies, two types of task durations based on 2 half-lives significantly outperformed the accuracies using fully acquired trials, supporting this length as the OST for the SST. In conclusion, we demonstrate the potential of a neuroadaptive task design that can be widely applied to personalizing other task-based fMRI experiments in either dynamic real-time fMRI applications or within fMRI preprocessing pipelines. |
| first_indexed | 2024-12-13T08:47:42Z |
| format | Article |
| id | doaj.art-baf81dc948c64adeabb8d4c1a200a50b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T08:47:42Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-baf81dc948c64adeabb8d4c1a200a50b2022-12-21T23:53:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020735210.1371/journal.pone.0207352Individual differences in rate of acquiring stable neural representations of tasks in fMRI.Ming-Hua ChungBradford MartinsAnthony PrivratskyG Andrew JamesClint D KiltsKeith A BushTask-related functional magnetic resonance imaging (fMRI) is a widely-used tool for studying the neural processing correlates of human behavior in both healthy and clinical populations. There is growing interest in mapping individual differences in fMRI task behavior and neural responses. By utilizing neuroadaptive task designs accounting for such individual differences, task durations can be personalized to potentially optimize neuroimaging study outcomes (e.g., classification of task-related brain states). To test this hypothesis, we first retrospectively tracked the volume-by-volume changes of beta weights generated from general linear models (GLM) for 67 adult subjects performing a stop-signal task (SST). We then modeled the convergence of the volume-by-volume changes of beta weights according to their exponential decay (ED) in units of half-life. Our results showed significant differences in beta weight convergence estimates of optimal stopping times (OSTs) between go following successful stop trials and failed stop trials for both cocaine dependent (CD) and control group (Con), and between go following successful stop trials and go following failed stop trials for Con group. Further, we implemented support vector machine (SVM) classification for 67 CD/Con labeled subjects and compared the classification accuracies of fMRI-based features derived from (1) the full fMRI task versus (2) the fMRI task truncated to multiples of the unit of half-life. Among the computed binary classification accuracies, two types of task durations based on 2 half-lives significantly outperformed the accuracies using fully acquired trials, supporting this length as the OST for the SST. In conclusion, we demonstrate the potential of a neuroadaptive task design that can be widely applied to personalizing other task-based fMRI experiments in either dynamic real-time fMRI applications or within fMRI preprocessing pipelines.http://europepmc.org/articles/PMC6261022?pdf=render |
| spellingShingle | Ming-Hua Chung Bradford Martins Anthony Privratsky G Andrew James Clint D Kilts Keith A Bush Individual differences in rate of acquiring stable neural representations of tasks in fMRI. PLoS ONE |
| title | Individual differences in rate of acquiring stable neural representations of tasks in fMRI. |
| title_full | Individual differences in rate of acquiring stable neural representations of tasks in fMRI. |
| title_fullStr | Individual differences in rate of acquiring stable neural representations of tasks in fMRI. |
| title_full_unstemmed | Individual differences in rate of acquiring stable neural representations of tasks in fMRI. |
| title_short | Individual differences in rate of acquiring stable neural representations of tasks in fMRI. |
| title_sort | individual differences in rate of acquiring stable neural representations of tasks in fmri |
| url | http://europepmc.org/articles/PMC6261022?pdf=render |
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