Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr

Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr

ABSTRACT The molecular basis of reduced susceptibility to amphotericin B (rs-AMB) among any yeasts is poorly defined. Genetic alterations in genes involved in ergosterol biosynthesis and total cell sterols were investigated among clinical Candida kefyr isolates. C. kefyr isolates (n = 81) obtained f...

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Bibliographic Details
Main Authors: Mohammad Asadzadeh, Wadha Alfouzan, Josie E. Parker, Jacques F. Meis, Steven L. Kelly, Leena Joseph, Suhail Ahmad
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
Candida kefyr
ERG2
nonsynonymous mutations
reduced susceptibility
amphotericin B
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01474-23

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