Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small‐cell lung cancer and enhance the efficacy of platinum‐based chemotherapy

Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small‐cell lung cancer and enhance the efficacy of platinum‐based chemotherapy

Abstract Background Small‐cell lung cancer (SCLC) is characterized by its high malignancy and is associated with a poor prognosis. In the early stages of the disease, platinum‐based chemotherapy is the recommended first‐line treatment and has demonstrated efficacy. However, SCLC is prone to recurren...

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Bibliographic Details
Main Authors: Anqi Lin, Weiming Mou, Lingxuan Zhu, Tao Yang, Chaozheng Zhou, Jian Zhang, Peng Luo
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Cancer Innovation
Subjects:
chemotherapy resistance
platinum
prognosis
small‐cell lung cancer
tumor microenvironment
Online Access:https://doi.org/10.1002/cai2.84

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