Influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis subject to sex belonging in Russian ethnic group

Influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis subject to sex belonging in Russian ethnic group

To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis (MS) subject to sex belonging in Omsk city and Omsk region. Methods: neurological examination, molecular-genetic, statistic...

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Bibliographic Details
Main Authors: Ye. V. Khanokh, A. S. Rozhdestvensky, Ye. A. Kudryavtseva, A. V. Kakulya, R. A. Delov, M. A. Filipenko
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2011-04-01
Series:Бюллетень сибирской медицины
Subjects:
рассеянный склероз
rs1800629 (tnfa)
rs6074022 (cd40)
rs187238 (il-18)
rs10492972 (kif1b)
rs4149584 (tnfrsf1a)
Online Access:https://bulletin.ssmu.ru/jour/article/view/1359
Description
Summary:To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis (MS) subject to sex belonging in Omsk city and Omsk region. Methods: neurological examination, molecular-genetic, statistic analyses. 265 patients with multiple sclerosis and 576 healthy controls was observed. Results: observable polymorphic loci don’t associated with sex. In group of men dysfunction of the pyramidal, visual, pelvic functions on course of MS, in women group — dysfunction of the pyramidal functions, duration of the disease, height, CD40 genotipe.
ISSN:1682-0363
1819-3684

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