Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum

Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum

The C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) is associated with neoplastic transformation, inflammation, neurodegenerative diseases and aging, and the small molecule inhibitor KAND567 targeting CX3CR1 (CX3CR1i) is evaluated in clinical trials for acute systemic inflammation u...

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Bibliographic Details
Main Authors: Jemina Lehto, Anna Huguet Ninou, Dimitrios Chioureas, Jos Jonkers, Nina M. S. Gustafsson
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
CX3CR1
FANCD2
replication
Fanconi anemia pathway
KAND567
Online Access:https://www.mdpi.com/2072-6694/13/6/1442

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