Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma
Taking into account the unpredictable evolution of uterine STUMP and leiomyosarcomas, there are no clearly established therapeutic protocols to date, the only certified treatment being total hysterectomy. We performed a 5-year retrospective study including cases of malignant tumors and those with un...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/12/6/94 |
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| author | Madalina Bosoteanu Mariana Deacu Raluca Ioana Voda Cristian Ionut Orasanu Mariana Aschie Sabina Elena Vlad Roxana Cleopatra Penciu Sergiu Ioachim Chirila |
| author_facet | Madalina Bosoteanu Mariana Deacu Raluca Ioana Voda Cristian Ionut Orasanu Mariana Aschie Sabina Elena Vlad Roxana Cleopatra Penciu Sergiu Ioachim Chirila |
| author_sort | Madalina Bosoteanu |
| collection | DOAJ |
| description | Taking into account the unpredictable evolution of uterine STUMP and leiomyosarcomas, there are no clearly established therapeutic protocols to date, the only certified treatment being total hysterectomy. We performed a 5-year retrospective study including cases of malignant tumors and those with uncertain malignant potential originating in the smooth muscle tissue of the uterine body. The clinical data, pathological aspects, and the immunohistochemical results were statistically analyzed using SPSS Statistics Version 26. The main associations of the p53 gene were identified with age, atypia, and the occurrence of metastases. The average number of CD8+ T cells correlated with the hormonal status of the patients, the presence of diabetes, and alteration of thyroid function, but also with the severity of the atypia. The therapeutic method was represented by total hysterectomy, and 30% of the patients with leiomyosarcoma also benefited from adjuvant chemotherapy. The average period until death was 25.66 months. The present study showed that the mutant expression of p53 could have a role in assessing the clinical evolution of patients, given the association with exitus and metastasis. In addition, the average number of CD8+ T cells corresponded to severe atypia, indicating the possibility of applying targeted immunotherapies in these cases. |
| first_indexed | 2024-03-09T17:10:38Z |
| format | Article |
| id | doaj.art-bafeeca0130244d49873ebf82ee1335d |
| institution | Directory Open Access Journal |
| issn | 2039-7283 |
| language | English |
| last_indexed | 2024-03-09T17:10:38Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-bafeeca0130244d49873ebf82ee1335d2023-11-24T14:05:10ZengMDPI AGClinics and Practice2039-72832022-11-0112689790710.3390/clinpract12060094Five-Year Retrospective Study of Uterine STUMP and LeiomyosarcomaMadalina Bosoteanu0Mariana Deacu1Raluca Ioana Voda2Cristian Ionut Orasanu3Mariana Aschie4Sabina Elena Vlad5Roxana Cleopatra Penciu6Sergiu Ioachim Chirila7Clinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, RomaniaCenter for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, “Ovidius” University of Constanta, 900591 Constanta, RomaniaDepartment of Obstetrics and Gynecology, Faculty of Medicine, “Ovidius” University of Constanta, 900527 Constanta, RomaniaMedical Informatics and Biostatistics, Faculty of Medicine, Ovidius University, 900527 Constanta, RomaniaTaking into account the unpredictable evolution of uterine STUMP and leiomyosarcomas, there are no clearly established therapeutic protocols to date, the only certified treatment being total hysterectomy. We performed a 5-year retrospective study including cases of malignant tumors and those with uncertain malignant potential originating in the smooth muscle tissue of the uterine body. The clinical data, pathological aspects, and the immunohistochemical results were statistically analyzed using SPSS Statistics Version 26. The main associations of the p53 gene were identified with age, atypia, and the occurrence of metastases. The average number of CD8+ T cells correlated with the hormonal status of the patients, the presence of diabetes, and alteration of thyroid function, but also with the severity of the atypia. The therapeutic method was represented by total hysterectomy, and 30% of the patients with leiomyosarcoma also benefited from adjuvant chemotherapy. The average period until death was 25.66 months. The present study showed that the mutant expression of p53 could have a role in assessing the clinical evolution of patients, given the association with exitus and metastasis. In addition, the average number of CD8+ T cells corresponded to severe atypia, indicating the possibility of applying targeted immunotherapies in these cases.https://www.mdpi.com/2039-7283/12/6/94uterusSTUMPleiomyosarcomastatisticsp53CD8 |
| spellingShingle | Madalina Bosoteanu Mariana Deacu Raluca Ioana Voda Cristian Ionut Orasanu Mariana Aschie Sabina Elena Vlad Roxana Cleopatra Penciu Sergiu Ioachim Chirila Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma Clinics and Practice uterus STUMP leiomyosarcoma statistics p53 CD8 |
| title | Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma |
| title_full | Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma |
| title_fullStr | Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma |
| title_full_unstemmed | Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma |
| title_short | Five-Year Retrospective Study of Uterine STUMP and Leiomyosarcoma |
| title_sort | five year retrospective study of uterine stump and leiomyosarcoma |
| topic | uterus STUMP leiomyosarcoma statistics p53 CD8 |
| url | https://www.mdpi.com/2039-7283/12/6/94 |
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