The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin
The yellow-flowering plant <i>Cladanthus arabicus</i> (L.) Cass., commonly called Arabian <i>Cladanthus</i> or palm springs daisy, is typical of the West Mediterranean region and is particularly abundant in Morocco. The plant is used in traditional Moroccan medicine for the t...
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MDPI AG
2024-01-01
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| Series: | AppliedChem |
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| Online Access: | https://www.mdpi.com/2673-9623/4/1/2 |
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| author | Latifa Bouissane Christian Bailly |
| author_facet | Latifa Bouissane Christian Bailly |
| author_sort | Latifa Bouissane |
| collection | DOAJ |
| description | The yellow-flowering plant <i>Cladanthus arabicus</i> (L.) Cass., commonly called Arabian <i>Cladanthus</i> or palm springs daisy, is typical of the West Mediterranean region and is particularly abundant in Morocco. The plant is used in traditional Moroccan medicine for the treatment of diabetes and other ailments. Over the past 20 years, this abundant wild plant has been neglected from a phytochemical viewpoint. For the first time, the present review provides a survey of the pharmacological properties reported from extracts of <i>C. arabicus</i> and from essential oils derived from the aerial parts, mainly antimicrobial, antioxidant, and anti-inflammatory properties. The main bioactive natural products are discussed, with a focus on two rare sesquiterpenes of major interest, which are abundant in the stems and leaves: the 6,12-guaianolide cladantholide and the germacranolide sintenin. These sesquiterpene lactones and their analogues are presented to highlight their properties, extraction or total synthesis, and their therapeutic benefits. They both represent convenient biosourced precursors for the synthesis of derivatives. Sintenin may be used as a starting material for the design of hemi-synthetic germacradienolide-type costunolide or parthenolide derivatives. The 6,12-guaianolide scaffold of cladantholide offers opportunities to design novel arglabin derivatives. The therapeutic potential of the neglected and under-utilized plant <i>Cladanthus arabicus</i> and its original phytochemicals shall be explored further. |
| first_indexed | 2024-04-24T18:37:03Z |
| format | Article |
| id | doaj.art-bb009e1ab0e84fe1a1387a80a01d7814 |
| institution | Directory Open Access Journal |
| issn | 2673-9623 |
| language | English |
| last_indexed | 2024-04-24T18:37:03Z |
| publishDate | 2024-01-01 |
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| series | AppliedChem |
| spelling | doaj.art-bb009e1ab0e84fe1a1387a80a01d78142024-03-27T13:18:48ZengMDPI AGAppliedChem2673-96232024-01-0141152810.3390/appliedchem4010002The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and SinteninLatifa Bouissane0Christian Bailly1Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, BP 523, Beni-Mellal 23000, MoroccoInstitute of Pharmaceutical Chemistry Albert Lespagnol (ICPAL), Faculty of Pharmacy, University of Lille, Rue du Professeur Laguesse, BP-83, F-59006 Lille, FranceThe yellow-flowering plant <i>Cladanthus arabicus</i> (L.) Cass., commonly called Arabian <i>Cladanthus</i> or palm springs daisy, is typical of the West Mediterranean region and is particularly abundant in Morocco. The plant is used in traditional Moroccan medicine for the treatment of diabetes and other ailments. Over the past 20 years, this abundant wild plant has been neglected from a phytochemical viewpoint. For the first time, the present review provides a survey of the pharmacological properties reported from extracts of <i>C. arabicus</i> and from essential oils derived from the aerial parts, mainly antimicrobial, antioxidant, and anti-inflammatory properties. The main bioactive natural products are discussed, with a focus on two rare sesquiterpenes of major interest, which are abundant in the stems and leaves: the 6,12-guaianolide cladantholide and the germacranolide sintenin. These sesquiterpene lactones and their analogues are presented to highlight their properties, extraction or total synthesis, and their therapeutic benefits. They both represent convenient biosourced precursors for the synthesis of derivatives. Sintenin may be used as a starting material for the design of hemi-synthetic germacradienolide-type costunolide or parthenolide derivatives. The 6,12-guaianolide scaffold of cladantholide offers opportunities to design novel arglabin derivatives. The therapeutic potential of the neglected and under-utilized plant <i>Cladanthus arabicus</i> and its original phytochemicals shall be explored further.https://www.mdpi.com/2673-9623/4/1/2cladantholide<i>Cladanthus</i><i>Cladanthus arabicus</i>germacranolideguaianolidesesquiterpene |
| spellingShingle | Latifa Bouissane Christian Bailly The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin AppliedChem cladantholide <i>Cladanthus</i> <i>Cladanthus arabicus</i> germacranolide guaianolide sesquiterpene |
| title | The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin |
| title_full | The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin |
| title_fullStr | The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin |
| title_full_unstemmed | The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin |
| title_short | The Medicinal Moroccan Plant <i>Cladanthus arabicus</i> as a Prominent Source of Sesquiterpenes Cladantholide and Sintenin |
| title_sort | medicinal moroccan plant i cladanthus arabicus i as a prominent source of sesquiterpenes cladantholide and sintenin |
| topic | cladantholide <i>Cladanthus</i> <i>Cladanthus arabicus</i> germacranolide guaianolide sesquiterpene |
| url | https://www.mdpi.com/2673-9623/4/1/2 |
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