Mda level in colon tissue of the rats with colon cancer model treated with diallyl disulfide
<b>Aim: </b>This study was conducted to investigate the effect of diallyl disulfide, one of the bioactive compounds of garlic, on the malondialdehyde level of colon tissue in rats with azoxymethane-induced colon cancer.<p> <b>Materials and Methods:</b> A total of 58 mal...
| Päätekijät: | , |
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
| Julkaistu: |
Selcuk University Press
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| Sarja: | Eurasian Journal of Veterinary Sciences |
| Aiheet: | |
| Linkit: | http://eurasianjvetsci.org/pdf.php3?id=1425 |
| Yhteenveto: | <b>Aim: </b>This study was conducted to investigate the effect of diallyl disulfide, one
of the bioactive compounds of garlic, on the malondialdehyde level of colon
tissue in rats with azoxymethane-induced colon cancer.<p>
<b>Materials and Methods:</b> A total of 58 male Wistar Albino rats were used in
the study. The animals were divided into 5 groups. The first group was the
control group (n=12), the second group was the cancer group (n=12) treated
with azoxymethane (15 mg/kg body weight), the third group was the group to
whom only diallyl disulfide (DADS, 50 mg/kg body weight) was administered
(n=11), the fourth group was the group to whom azoxymethane and diallyl
disulfide were administered (n=11) and the fifth group was the group to
whom corn oil (1 ml/kg body weight) was administered as carrier substance
(n=12). The experimental the one which period at the end of 18 weeks, the
animals were sacrificed by cervical dislocation and their colon tissues were
excised. The tissues were homogenized and MDA levels were measured with
the ELISA device using the procedure, suitable for the kit.<p>
<b>Results:</b> Tumor formation in the tissues was macroscopically identified. The
analysis results indicated no difference between the groups with respect to
their MDA levels (P>0.05).<p>
<b>Conclusion:</b> In conclusion, it can be asserted that the administration of DADS
or azoxymethane did not cause lipid peroxidation in the rat colon tissue under
the experimental conditions. There is a need for further studies investigating
the effectiveness of DADS or AOM in colon tissue by taking the method and the
dose of treatment to the animals into consideration. |
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| ISSN: | 1309-6958 2146-1953 |