Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic
Treatment difficulties of COVID-19 have determined the need to identify predictive risk factors for the development of a complicated disease course, critical conditions and death. Endocrine and metabolic abnormalities associated with obesity, including impaired insulin sensitivity, chronic inflammat...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2020-12-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12663 |
| _version_ | 1797204554816684032 |
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| author | T. Yu. Demidova E. I. Volkova E. Yu. Gritskevich |
| author_facet | T. Yu. Demidova E. I. Volkova E. Yu. Gritskevich |
| author_sort | T. Yu. Demidova |
| collection | DOAJ |
| description | Treatment difficulties of COVID-19 have determined the need to identify predictive risk factors for the development of a complicated disease course, critical conditions and death. Endocrine and metabolic abnormalities associated with obesity, including impaired insulin sensitivity, chronic inflammation and impaired lipid and fatty acid metabolism, increase immunological dysregulation and make these patients more susceptible to developing infectious diseases. Research data allows us to single out obesity as a risk factor for the aggravated course of COVID-19, as well as a longer period before the virus elimination, and, therefore, the risk of virus transmission. Potentiation of cardiovascular risk factors, an increase in the production of pro-inflammatory cytokines, coagulopathy are factors in the development of unfavorable outcomes in such patients.This review presents literature data on the features of the course and the mechanisms of development of complications in patients with new coronavirus infection and obesity. Taking into account the need to restore metabolic health to increase the adaptive and resistant capacities of the body in the face of the threat of a new increase in the prevalence of COVID-19, the possibilities of treating obesity using a combined preparation containing sibutramine and metformin in one tablet, are discussed. |
| first_indexed | 2024-03-08T09:13:34Z |
| format | Article |
| id | doaj.art-bb042df2e9c840169165e46e7479aabf |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:05Z |
| publishDate | 2020-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-bb042df2e9c840169165e46e7479aabf2024-04-16T16:16:13ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242020-12-0117437538410.14341/omet1266310866Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemicT. Yu. Demidova0E. I. Volkova1E. Yu. Gritskevich2N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationN.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationN.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationTreatment difficulties of COVID-19 have determined the need to identify predictive risk factors for the development of a complicated disease course, critical conditions and death. Endocrine and metabolic abnormalities associated with obesity, including impaired insulin sensitivity, chronic inflammation and impaired lipid and fatty acid metabolism, increase immunological dysregulation and make these patients more susceptible to developing infectious diseases. Research data allows us to single out obesity as a risk factor for the aggravated course of COVID-19, as well as a longer period before the virus elimination, and, therefore, the risk of virus transmission. Potentiation of cardiovascular risk factors, an increase in the production of pro-inflammatory cytokines, coagulopathy are factors in the development of unfavorable outcomes in such patients.This review presents literature data on the features of the course and the mechanisms of development of complications in patients with new coronavirus infection and obesity. Taking into account the need to restore metabolic health to increase the adaptive and resistant capacities of the body in the face of the threat of a new increase in the prevalence of COVID-19, the possibilities of treating obesity using a combined preparation containing sibutramine and metformin in one tablet, are discussed.https://www.omet-endojournals.ru/jour/article/view/12663obesitycovid-19sibutraminemetforminreduxine®forte |
| spellingShingle | T. Yu. Demidova E. I. Volkova E. Yu. Gritskevich Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic Ожирение и метаболизм obesity covid-19 sibutramine metformin reduxine®forte |
| title | Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic |
| title_full | Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic |
| title_fullStr | Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic |
| title_full_unstemmed | Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic |
| title_short | Peculiarities of the COVID-19 course and consequences in overweight and obese patients. Lessons from the current pandemic |
| title_sort | peculiarities of the covid 19 course and consequences in overweight and obese patients lessons from the current pandemic |
| topic | obesity covid-19 sibutramine metformin reduxine®forte |
| url | https://www.omet-endojournals.ru/jour/article/view/12663 |
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