Statins in Cancer Prevention and Therapy
Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/15/3948 |
| _version_ | 1797586969230835712 |
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| author | Natalia Ricco Stephen J. Kron |
| author_facet | Natalia Ricco Stephen J. Kron |
| author_sort | Natalia Ricco |
| collection | DOAJ |
| description | Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy for which established treatment often fails despite incurring debilitating adverse effects. Preclinical and clinical studies have suggested that statins may enhance HNC sensitivity to radiation and other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent and -independent effects on diverse cancer-related pathways. This review brings together recent discoveries concerning the anticancer activity of statins relevant to HNC, highlighting their anti-inflammatory activity and impacts on DNA-damage response. We also explore molecular targets and mechanisms and discuss the potential to integrate statins into conventional HNC treatment regimens to improve patient outcomes. |
| first_indexed | 2024-03-11T00:30:41Z |
| format | Article |
| id | doaj.art-bb04c27738cd4b649b656c18feaa2c77 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:41Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bb04c27738cd4b649b656c18feaa2c772023-11-18T22:43:34ZengMDPI AGCancers2072-66942023-08-011515394810.3390/cancers15153948Statins in Cancer Prevention and TherapyNatalia Ricco0Stephen J. Kron1Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195 Barcelona, SpainDepartment of Molecular Genetics and Cell Biology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USAStatins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy for which established treatment often fails despite incurring debilitating adverse effects. Preclinical and clinical studies have suggested that statins may enhance HNC sensitivity to radiation and other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent and -independent effects on diverse cancer-related pathways. This review brings together recent discoveries concerning the anticancer activity of statins relevant to HNC, highlighting their anti-inflammatory activity and impacts on DNA-damage response. We also explore molecular targets and mechanisms and discuss the potential to integrate statins into conventional HNC treatment regimens to improve patient outcomes.https://www.mdpi.com/2072-6694/15/15/3948head and neck cancerstatincholesterolprenylationcancer therapyprevention |
| spellingShingle | Natalia Ricco Stephen J. Kron Statins in Cancer Prevention and Therapy Cancers head and neck cancer statin cholesterol prenylation cancer therapy prevention |
| title | Statins in Cancer Prevention and Therapy |
| title_full | Statins in Cancer Prevention and Therapy |
| title_fullStr | Statins in Cancer Prevention and Therapy |
| title_full_unstemmed | Statins in Cancer Prevention and Therapy |
| title_short | Statins in Cancer Prevention and Therapy |
| title_sort | statins in cancer prevention and therapy |
| topic | head and neck cancer statin cholesterol prenylation cancer therapy prevention |
| url | https://www.mdpi.com/2072-6694/15/15/3948 |
| work_keys_str_mv | AT nataliaricco statinsincancerpreventionandtherapy AT stephenjkron statinsincancerpreventionandtherapy |