| Summary: | The north-eastern region in Thailand is the largest in area and population. Its average income per capita is, however, the lowest in Thailand. This phenomenon leads to migration to big cities, which are considered economic centres. We investigated the effect of spatial interaction on the population density pattern in 20 provinces in north-eastern Thailand. Data was obtained from the compilation and preparation of the demographic data of 2676 sub-districts for 2002–2017. A field survey was conducted through GPS at educational institutions, hospitals, airports, government offices, and shopping malls. The data was analysed using spatial autocorrelation analysis by a global indicator (global Moran’s I) and a local indicator (local Moran’s I and Getis–Ord G<sub>i</sub>*). Eight Mueang districts exhibited the high-high (H-H) cluster pattern or hot spot at an increasing yearly rate. In addition, the area with the highest gravity was located near service sources and was found to have the largest population. Moreover, gravity interaction with service sources had a strong positive correlation with migration patterns. Thus, the cluster of areas with the greatest population density is located within the Mueang district in one of the provinces with most service sources, as these places attract people and consequently industrial factories and service trades.
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