Genome evolution in yeast reveals connections between rare mutations in human cancers
Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2014-06-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/genome-evolution-in-yeast-reveals-connections-between-rare-mutations-in-human-cancer/ |
| _version_ | 1811231631413870592 |
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| author | Xinchen Teng J. Marie Hardwick |
| author_facet | Xinchen Teng J. Marie Hardwick |
| author_sort | Xinchen Teng |
| collection | DOAJ |
| description | Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations. |
| first_indexed | 2024-04-12T10:48:23Z |
| format | Article |
| id | doaj.art-bb05a5838100411f8bf58afef4a77581 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-04-12T10:48:23Z |
| publishDate | 2014-06-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-bb05a5838100411f8bf58afef4a775812022-12-22T03:36:20ZengShared Science Publishers OGMicrobial Cell2311-26382014-06-011620620910.15698/mic2014.06.153Genome evolution in yeast reveals connections between rare mutations in human cancersXinchen Teng0J. Marie Hardwick1College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, PRChina.W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 USA.Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485–494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.http://microbialcell.com/researcharticles/genome-evolution-in-yeast-reveals-connections-between-rare-mutations-in-human-cancer/yeast knockoutsgenome evolutionsecondary mutationscancer progression |
| spellingShingle | Xinchen Teng J. Marie Hardwick Genome evolution in yeast reveals connections between rare mutations in human cancers Microbial Cell yeast knockouts genome evolution secondary mutations cancer progression |
| title | Genome evolution in yeast reveals connections between rare mutations in human cancers |
| title_full | Genome evolution in yeast reveals connections between rare mutations in human cancers |
| title_fullStr | Genome evolution in yeast reveals connections between rare mutations in human cancers |
| title_full_unstemmed | Genome evolution in yeast reveals connections between rare mutations in human cancers |
| title_short | Genome evolution in yeast reveals connections between rare mutations in human cancers |
| title_sort | genome evolution in yeast reveals connections between rare mutations in human cancers |
| topic | yeast knockouts genome evolution secondary mutations cancer progression |
| url | http://microbialcell.com/researcharticles/genome-evolution-in-yeast-reveals-connections-between-rare-mutations-in-human-cancer/ |
| work_keys_str_mv | AT xinchenteng genomeevolutioninyeastrevealsconnectionsbetweenraremutationsinhumancancers AT jmariehardwick genomeevolutioninyeastrevealsconnectionsbetweenraremutationsinhumancancers |