Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang
Highlights Sex differences exist in the prevalence, tumor invasiveness, treatment responses, and clinical outcomes of pan-cancer, suggesting that, while not yet incorporated, sex will probably be considered in future practice guidelines. Inherent genetic differences, overlapping epigenetic alteratio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-022-00469-5 |
| _version_ | 1797985985197244416 |
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| author | Junfu Ma Yanxin Yao Ye Tian Kexin Chen Ben Liu |
| author_facet | Junfu Ma Yanxin Yao Ye Tian Kexin Chen Ben Liu |
| author_sort | Junfu Ma |
| collection | DOAJ |
| description | Highlights Sex differences exist in the prevalence, tumor invasiveness, treatment responses, and clinical outcomes of pan-cancer, suggesting that, while not yet incorporated, sex will probably be considered in future practice guidelines. Inherent genetic differences, overlapping epigenetic alterations, and sex hormone influences underpin everything. Androgen receptors influence the sexual differences in TME by regulating epigenetic and transcriptional differentiation programs. It highlights a sex-based therapeutic target for cancer immunotherapy. Proper consideration of sex, age, sex hormones/menopause status, and socio-cultural gender differences in clinical investigation and gene association studies of cancer are needed to fill current gaps and implement precision medicine for patients with cancer. |
| first_indexed | 2024-04-11T07:26:51Z |
| format | Article |
| id | doaj.art-bb0816620d1243a483e3b2f045131598 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-11T07:26:51Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-bb0816620d1243a483e3b2f0451315982022-12-22T04:37:04ZengBMCBiology of Sex Differences2042-64102022-10-0113111210.1186/s13293-022-00469-5Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and YangJunfu Ma0Yanxin Yao1Ye Tian2Kexin Chen3Ben Liu4Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical UniversityDepartment of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical UniversityDepartment of Senior Ward, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and HospitalDepartment of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical UniversityDepartment of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical UniversityHighlights Sex differences exist in the prevalence, tumor invasiveness, treatment responses, and clinical outcomes of pan-cancer, suggesting that, while not yet incorporated, sex will probably be considered in future practice guidelines. Inherent genetic differences, overlapping epigenetic alterations, and sex hormone influences underpin everything. Androgen receptors influence the sexual differences in TME by regulating epigenetic and transcriptional differentiation programs. It highlights a sex-based therapeutic target for cancer immunotherapy. Proper consideration of sex, age, sex hormones/menopause status, and socio-cultural gender differences in clinical investigation and gene association studies of cancer are needed to fill current gaps and implement precision medicine for patients with cancer.https://doi.org/10.1186/s13293-022-00469-5Sex disparitiesCancer immunotherapyImmune checkpoint inhibitors (ICIs)BiomarkerPrecision medicine |
| spellingShingle | Junfu Ma Yanxin Yao Ye Tian Kexin Chen Ben Liu Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang Biology of Sex Differences Sex disparities Cancer immunotherapy Immune checkpoint inhibitors (ICIs) Biomarker Precision medicine |
| title | Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang |
| title_full | Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang |
| title_fullStr | Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang |
| title_full_unstemmed | Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang |
| title_short | Advances in sex disparities for cancer immunotherapy: unveiling the dilemma of Yin and Yang |
| title_sort | advances in sex disparities for cancer immunotherapy unveiling the dilemma of yin and yang |
| topic | Sex disparities Cancer immunotherapy Immune checkpoint inhibitors (ICIs) Biomarker Precision medicine |
| url | https://doi.org/10.1186/s13293-022-00469-5 |
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