血清钠水平与高血压患者新发糖尿病呈负相关
Abstract Background Serum sodium level is associated with cardiovascular and endocrine health. Though decreased serum sodium is considered to be associated with reduced hypertension risk, some studies also found that it may increase the risk of diabetes. This study aimed to investigate the associati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13338 |
| _version_ | 1797978037240725504 |
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| author | Qi Cheng Xiaocong Liu Anping Cai Dan Zhou Yuqing Huang Yingqing Feng |
| author_facet | Qi Cheng Xiaocong Liu Anping Cai Dan Zhou Yuqing Huang Yingqing Feng |
| author_sort | Qi Cheng |
| collection | DOAJ |
| description | Abstract Background Serum sodium level is associated with cardiovascular and endocrine health. Though decreased serum sodium is considered to be associated with reduced hypertension risk, some studies also found that it may increase the risk of diabetes. This study aimed to investigate the association of serum sodium with new‐onset diabetes in hypertensive patients. Methods Based on the annual health examinations from 2011 to 2016 in Dongguan City, Guangdong, China, hypertensive patients without diabetes at baseline were selected. Logistic regression and restricted cubic spline were used to evaluate the association between serum sodium level and new‐onset diabetes. Subgroup analysis was also conducted. Results A total of 4438 hypertensive patients with a mean age of 58.65 years were included, of whom 48.9% were male. During a median follow‐up of 35.1 months, 617 (13.9%) of the subjects developed new‐onset diabetes. Per 1‐SD (3.39 mmol/L) increment of serum sodium was associated with a 14% lower risk of new‐onset diabetes (odds ratio = 0.86; 95% CI: 0.78, 0.97; p = 0.01). The lowest quartile of serum sodium was associated with the lowest diabetes risk. The restricted cubic spline showed a linear inverse relationship (nonlinear p = 0.72). Across all the subgroups, the inverse association was consistent (p for interaction >0.05). Conclusion An inverse association of serum sodium with new‐onset diabetes in hypertensive patients was observed. |
| first_indexed | 2024-04-11T05:16:37Z |
| format | Article |
| id | doaj.art-bb08747ac4bf4c54846af0d8461fd0bc |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-11T05:16:37Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-bb08747ac4bf4c54846af0d8461fd0bc2022-12-24T08:16:32ZengWileyJournal of Diabetes1753-03931753-04072022-12-01141283183910.1111/1753-0407.13338血清钠水平与高血压患者新发糖尿病呈负相关Qi Cheng0Xiaocong Liu1Anping Cai2Dan Zhou3Yuqing Huang4Yingqing Feng5Department of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong ChinaDepartment of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong ChinaDepartment of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong ChinaDepartment of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong ChinaDepartment of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong ChinaDepartment of Cardiology Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong ChinaAbstract Background Serum sodium level is associated with cardiovascular and endocrine health. Though decreased serum sodium is considered to be associated with reduced hypertension risk, some studies also found that it may increase the risk of diabetes. This study aimed to investigate the association of serum sodium with new‐onset diabetes in hypertensive patients. Methods Based on the annual health examinations from 2011 to 2016 in Dongguan City, Guangdong, China, hypertensive patients without diabetes at baseline were selected. Logistic regression and restricted cubic spline were used to evaluate the association between serum sodium level and new‐onset diabetes. Subgroup analysis was also conducted. Results A total of 4438 hypertensive patients with a mean age of 58.65 years were included, of whom 48.9% were male. During a median follow‐up of 35.1 months, 617 (13.9%) of the subjects developed new‐onset diabetes. Per 1‐SD (3.39 mmol/L) increment of serum sodium was associated with a 14% lower risk of new‐onset diabetes (odds ratio = 0.86; 95% CI: 0.78, 0.97; p = 0.01). The lowest quartile of serum sodium was associated with the lowest diabetes risk. The restricted cubic spline showed a linear inverse relationship (nonlinear p = 0.72). Across all the subgroups, the inverse association was consistent (p for interaction >0.05). Conclusion An inverse association of serum sodium with new‐onset diabetes in hypertensive patients was observed.https://doi.org/10.1111/1753-0407.13338血清钠新发糖尿病高血压 |
| spellingShingle | Qi Cheng Xiaocong Liu Anping Cai Dan Zhou Yuqing Huang Yingqing Feng 血清钠水平与高血压患者新发糖尿病呈负相关 Journal of Diabetes 血清钠 新发糖尿病 高血压 |
| title | 血清钠水平与高血压患者新发糖尿病呈负相关 |
| title_full | 血清钠水平与高血压患者新发糖尿病呈负相关 |
| title_fullStr | 血清钠水平与高血压患者新发糖尿病呈负相关 |
| title_full_unstemmed | 血清钠水平与高血压患者新发糖尿病呈负相关 |
| title_short | 血清钠水平与高血压患者新发糖尿病呈负相关 |
| title_sort | 血清钠水平与高血压患者新发糖尿病呈负相关 |
| topic | 血清钠 新发糖尿病 高血压 |
| url | https://doi.org/10.1111/1753-0407.13338 |
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