Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA
Many uncommon Candida species that cause bloodstream infections (BSIs) are not well-characterized. We investigated the epidemiology, antifungal use, susceptibility patterns, and factors associated with all-cause death among cancer patients in whom uncommon Candida spp. BSIs were diagnosed at a cance...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2015-11-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/21/11/15-0404_article |
| _version_ | 1818108140978176000 |
|---|---|
| author | Dong Sik Jung Dimitrios Farmakiotis Ying Jiang Jeffrey J. Tarrand Dimitrios P. Kontoyiannis |
| author_facet | Dong Sik Jung Dimitrios Farmakiotis Ying Jiang Jeffrey J. Tarrand Dimitrios P. Kontoyiannis |
| author_sort | Dong Sik Jung |
| collection | DOAJ |
| description | Many uncommon Candida species that cause bloodstream infections (BSIs) are not well-characterized. We investigated the epidemiology, antifungal use, susceptibility patterns, and factors associated with all-cause death among cancer patients in whom uncommon Candida spp. BSIs were diagnosed at a cancer treatment center during January 1998–September 2013. Of 1,395 Candida bloodstream isolates, 79 from 68 patients were uncommon Candida spp. The incidence density of uncommon Candida spp. BSIs and their proportion to all candidemia episodes substantively increased during the study period, and the rise was associated with increasing use of echinocandin antifungal drugs. Thirty-seven patients had breakthrough infections during therapy or prophylaxis with various systemic antifungal drugs for >7 consecutive days; 21 were receiving an echinocandin. C. kefyr (82%), and C. lusitaniae (21%) isolates frequently showed caspofungin MICs above the epidemiologic cutoff values. These findings support the need for institutional surveillance for uncommon Candida spp. among cancer patients. |
| first_indexed | 2024-12-11T02:10:38Z |
| format | Article |
| id | doaj.art-bb0896011f6c4b84a23d75c28671be88 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T02:10:38Z |
| publishDate | 2015-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-bb0896011f6c4b84a23d75c28671be882022-12-22T01:24:16ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-11-0121111942195010.3201/eid2111.150404Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USADong Sik JungDimitrios FarmakiotisYing JiangJeffrey J. TarrandDimitrios P. KontoyiannisMany uncommon Candida species that cause bloodstream infections (BSIs) are not well-characterized. We investigated the epidemiology, antifungal use, susceptibility patterns, and factors associated with all-cause death among cancer patients in whom uncommon Candida spp. BSIs were diagnosed at a cancer treatment center during January 1998–September 2013. Of 1,395 Candida bloodstream isolates, 79 from 68 patients were uncommon Candida spp. The incidence density of uncommon Candida spp. BSIs and their proportion to all candidemia episodes substantively increased during the study period, and the rise was associated with increasing use of echinocandin antifungal drugs. Thirty-seven patients had breakthrough infections during therapy or prophylaxis with various systemic antifungal drugs for >7 consecutive days; 21 were receiving an echinocandin. C. kefyr (82%), and C. lusitaniae (21%) isolates frequently showed caspofungin MICs above the epidemiologic cutoff values. These findings support the need for institutional surveillance for uncommon Candida spp. among cancer patients.https://wwwnc.cdc.gov/eid/article/21/11/15-0404_articleCandidacancercandidemiaechinocandin. C. kefyrC. lusitaniaenon-albicans |
| spellingShingle | Dong Sik Jung Dimitrios Farmakiotis Ying Jiang Jeffrey J. Tarrand Dimitrios P. Kontoyiannis Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA Emerging Infectious Diseases Candida cancer candidemia echinocandin. C. kefyr C. lusitaniae non-albicans |
| title | Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA |
| title_full | Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA |
| title_fullStr | Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA |
| title_full_unstemmed | Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA |
| title_short | Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA |
| title_sort | uncommon candida species fungemia among cancer patients houston texas usa |
| topic | Candida cancer candidemia echinocandin. C. kefyr C. lusitaniae non-albicans |
| url | https://wwwnc.cdc.gov/eid/article/21/11/15-0404_article |
| work_keys_str_mv | AT dongsikjung uncommoncandidaspeciesfungemiaamongcancerpatientshoustontexasusa AT dimitriosfarmakiotis uncommoncandidaspeciesfungemiaamongcancerpatientshoustontexasusa AT yingjiang uncommoncandidaspeciesfungemiaamongcancerpatientshoustontexasusa AT jeffreyjtarrand uncommoncandidaspeciesfungemiaamongcancerpatientshoustontexasusa AT dimitriospkontoyiannis uncommoncandidaspeciesfungemiaamongcancerpatientshoustontexasusa |