The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats
Aim:Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability.Methods:Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2019-09-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/the-effect-of-iquercus-coccifera-l-i-extract-on-th/30296
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| Summary: | Aim:Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability.Methods:Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7.Results:The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively).Conclusions:Necrosis of skin flaps was decreased through application of Q. coccifera extracts. |
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| ISSN: | 1302-0072 2147-2688 |