Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency
Purpose It is well known that obesity is related to vitamin D deficiency (VDD). We investigated the response to vitamin D replacement in normal-weight and overweight children. Methods This was a prospective study including 62 Korean children with VDD. VDD was defined as a serum 25-hydroxycholecalcif...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2019-03-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-2019-24-1-22.pdf |
| _version_ | 1818925917080125440 |
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| author | In Hyuk Chung Yu Sun Kang Eun-Gyong Yoo |
| author_facet | In Hyuk Chung Yu Sun Kang Eun-Gyong Yoo |
| author_sort | In Hyuk Chung |
| collection | DOAJ |
| description | Purpose It is well known that obesity is related to vitamin D deficiency (VDD). We investigated the response to vitamin D replacement in normal-weight and overweight children. Methods This was a prospective study including 62 Korean children with VDD. VDD was defined as a serum 25-hydroxycholecalciferol (25(OH)D) concentration <20 ng/mL. Overweight was defined as a body mass index (BMI)≥the 85th percentile (n=21), and normal weight as a BMI between the 5th and 84th percentiles (n=41). All participants received vitamin D3 supplementation (2,000 IU/day) for 8 weeks. The serum levels of 25(OH)D, PTH and biochemical parameters were measured before and after treatment. Results The mean age was 10.0±1.4 years in normal-weight children and 10.0±2.1 years in overweight children (P=0.93). After 8 weeks of treatment, 61.9% of normal-weight children and 47.6% of overweight children achieved vitamin D sufficiency (P =0.30). The mean serum 25(OH)D levels after vitamin D replacement were 33.8±7.6 ng/mL and 30.3±6.6 ng/mL in normal-weight and overweight children, respectively (P =0.10). The mean calcium/creatinine ratios after treatment were 0.09±0.07 and 0.08±0.06 in the normal-weight and overweight groups, respectively, and no hypercalciuria was found. In multiple regression analysis, the response to vitamin D replacement was influenced by the BMI (β=-1.0, P=0.03) and sex (β=-4.0, P=0.04). Conclusions Eight weeks of vitamin D replacement (2,000 IU/day) is sufficient to overcome vitamin D deficiency in normal-weight and overweight children without any complications. |
| first_indexed | 2024-12-20T02:48:50Z |
| format | Article |
| id | doaj.art-bb0af9e8c35e4daea4ada2c56671f1e4 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-20T02:48:50Z |
| publishDate | 2019-03-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-bb0af9e8c35e4daea4ada2c56671f1e42022-12-21T19:56:06ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922019-03-01241222610.6065/apem.2019.24.1.22762Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiencyIn Hyuk Chung0Yu Sun Kang1Eun-Gyong Yoo2 Department of Pediatrics, National Health Corporation Ilsan Hospital, Goyang, Korea Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, KoreaPurpose It is well known that obesity is related to vitamin D deficiency (VDD). We investigated the response to vitamin D replacement in normal-weight and overweight children. Methods This was a prospective study including 62 Korean children with VDD. VDD was defined as a serum 25-hydroxycholecalciferol (25(OH)D) concentration <20 ng/mL. Overweight was defined as a body mass index (BMI)≥the 85th percentile (n=21), and normal weight as a BMI between the 5th and 84th percentiles (n=41). All participants received vitamin D3 supplementation (2,000 IU/day) for 8 weeks. The serum levels of 25(OH)D, PTH and biochemical parameters were measured before and after treatment. Results The mean age was 10.0±1.4 years in normal-weight children and 10.0±2.1 years in overweight children (P=0.93). After 8 weeks of treatment, 61.9% of normal-weight children and 47.6% of overweight children achieved vitamin D sufficiency (P =0.30). The mean serum 25(OH)D levels after vitamin D replacement were 33.8±7.6 ng/mL and 30.3±6.6 ng/mL in normal-weight and overweight children, respectively (P =0.10). The mean calcium/creatinine ratios after treatment were 0.09±0.07 and 0.08±0.06 in the normal-weight and overweight groups, respectively, and no hypercalciuria was found. In multiple regression analysis, the response to vitamin D replacement was influenced by the BMI (β=-1.0, P=0.03) and sex (β=-4.0, P=0.04). Conclusions Eight weeks of vitamin D replacement (2,000 IU/day) is sufficient to overcome vitamin D deficiency in normal-weight and overweight children without any complications.http://e-apem.org/upload/pdf/apem-2019-24-1-22.pdfVitamin DChildSupplementOverweightObesity |
| spellingShingle | In Hyuk Chung Yu Sun Kang Eun-Gyong Yoo Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency Annals of Pediatric Endocrinology & Metabolism Vitamin D Child Supplement Overweight Obesity |
| title | Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency |
| title_full | Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency |
| title_fullStr | Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency |
| title_full_unstemmed | Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency |
| title_short | Response to vitamin D replacement in overweight and normal weight children with vitamin D deficiency |
| title_sort | response to vitamin d replacement in overweight and normal weight children with vitamin d deficiency |
| topic | Vitamin D Child Supplement Overweight Obesity |
| url | http://e-apem.org/upload/pdf/apem-2019-24-1-22.pdf |
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