Role of sodium/iodide symporter overexpression in inhibiting thyroid cancer cell invasion and stem cell maintenance by inhibiting the β-catenin/LEF-1 pathway

Role of sodium/iodide symporter overexpression in inhibiting thyroid cancer cell invasion and stem cell maintenance by inhibiting the β-catenin/LEF-1 pathway

Background: In thyroid cancers, a reduction in the expression of the sodium/iodide symporter (NIS) is observed concomitant with a diminution in cancer cell differentiation. The β-catenin/LEF-1 pathway emerges as a crucial regulatory pathway influencing the functional expression of NIS in human thyro...

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Bibliographic Details
Main Authors:	Nan-Fang Luo, Jia-Li Li, Juan Lv, Fu-Kun Chen, Ya-Nan Li, Ming Tang, Peng-Jie Liu
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Series:	Heliyon
Subjects:	β-Catenin LEF-1 Papillary thyroid carcinoma Sodium iodide symporter (NIS)
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024038714

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