Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2

Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2

Abstract Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) that displayed a strong apoptotic potential in Jurkat leukemia and Ramos lymphoma cells. Meriolin 16 indu...

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Bibliographic Details
Main Authors: Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01901-y

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https://doi.org/10.1038/s41420-024-01901-y

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