ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. For many years, viruses have been suspected as causative agents. There are conflicting reports about the possible role of viruses such as human herpes virus 8 (HHV8) and retroviruses in the pathogenesis...

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Main Authors: A. Tarazi, S. Nafissi, A. A. Amirzargar, P. Ayatollahi A. Soltanzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2006-08-01
Series:Acta Medica Iranica
Subjects:
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3009.pdf&manuscript_id=3009
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author A. Tarazi
S. Nafissi
A. A. Amirzargar
P. Ayatollahi A. Soltanzadeh
author_facet A. Tarazi
S. Nafissi
A. A. Amirzargar
P. Ayatollahi A. Soltanzadeh
author_sort A. Tarazi
collection DOAJ
description Amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. For many years, viruses have been suspected as causative agents. There are conflicting reports about the possible role of viruses such as human herpes virus 8 (HHV8) and retroviruses in the pathogenesis of the sporadic amyotrophic lateral sclerosis. We conducted a prospective case-control study to investigate the association of seropositivity of HHV8, human T lymphotropic virus 1 (HTLV1) and human immunodeficiency virus (HIV) with risk of amyotrophic lateral sclerosis. Thirty patients with confirmed amyotrophic lateral sclerosis and 30 controls matched by sex and age were included in this study. Enzyme immunoassays for the determination of antibodies to HHV8, HTLV1 and HIV were performed on the serum samples of cases and controls. For HHV8, one in case group and one in control group were considered reactive for anti HHV8 IgG. For HTLV1 and HIV, the results were negative in both groups. This study does not support any association between seropositivity of HHV8, HIV and HTLV1 with amyotrophic lateral sclerosis.
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spelling doaj.art-bb0f70a111794256a17576e0a403c1f72022-12-22T01:30:39ZengTehran University of Medical SciencesActa Medica Iranica0044-60252006-08-01444256258ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8A. TaraziS. NafissiA. A. AmirzargarP. Ayatollahi A. SoltanzadehAmyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. For many years, viruses have been suspected as causative agents. There are conflicting reports about the possible role of viruses such as human herpes virus 8 (HHV8) and retroviruses in the pathogenesis of the sporadic amyotrophic lateral sclerosis. We conducted a prospective case-control study to investigate the association of seropositivity of HHV8, human T lymphotropic virus 1 (HTLV1) and human immunodeficiency virus (HIV) with risk of amyotrophic lateral sclerosis. Thirty patients with confirmed amyotrophic lateral sclerosis and 30 controls matched by sex and age were included in this study. Enzyme immunoassays for the determination of antibodies to HHV8, HTLV1 and HIV were performed on the serum samples of cases and controls. For HHV8, one in case group and one in control group were considered reactive for anti HHV8 IgG. For HTLV1 and HIV, the results were negative in both groups. This study does not support any association between seropositivity of HHV8, HIV and HTLV1 with amyotrophic lateral sclerosis.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3009.pdf&manuscript_id=3009Amyotrophic lateral sclerosisviral infectionshuman herpesvirus 8human T lymphotropic virus 1
spellingShingle A. Tarazi
S. Nafissi
A. A. Amirzargar
P. Ayatollahi A. Soltanzadeh
ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8
Acta Medica Iranica
Amyotrophic lateral sclerosis
viral infections
human herpesvirus 8
human T lymphotropic virus 1
title ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8
title_full ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8
title_fullStr ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8
title_full_unstemmed ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8
title_short ASSOCIATION OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS WITH HUMAN T LYMPHO-TROPIC VIRUS 1, HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HERPES VIRUS 8
title_sort association of sporadic amyotrophic lateral sclerosis with human t lympho tropic virus 1 human immunodeficiency virus and human herpes virus 8
topic Amyotrophic lateral sclerosis
viral infections
human herpesvirus 8
human T lymphotropic virus 1
url http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3009.pdf&manuscript_id=3009
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AT snafissi associationofsporadicamyotrophiclateralsclerosiswithhumantlymphotropicvirus1humanimmunodeficiencyvirusandhumanherpesvirus8
AT aaamirzargar associationofsporadicamyotrophiclateralsclerosiswithhumantlymphotropicvirus1humanimmunodeficiencyvirusandhumanherpesvirus8
AT payatollahiasoltanzadeh associationofsporadicamyotrophiclateralsclerosiswithhumantlymphotropicvirus1humanimmunodeficiencyvirusandhumanherpesvirus8