Voltage and spike timing interact in STDP - a unified model
A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on Spike-Timing Dependent Plasticity. The basic ingredient of the model is the correlation of presynaptic spike arrival with postsynaptic voltage. The local membrane voltage is used twice: a firs...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-07-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00025/full |
| _version_ | 1818563730894487552 |
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| author | Claudia Clopath Claudia Clopath Wulfram Gerstner |
| author_facet | Claudia Clopath Claudia Clopath Wulfram Gerstner |
| author_sort | Claudia Clopath |
| collection | DOAJ |
| description | A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on Spike-Timing Dependent Plasticity. The basic ingredient of the model is the correlation of presynaptic spike arrival with postsynaptic voltage. The local membrane voltage is used twice: a first term account for the instantaneous voltage and the second one on a low-pass filtered voltage trace. Spike-Timing effects emerge as a special case. We hypothesize that the voltage dependence can explain differential effects of STDP in dendrites, since the amplitude of time course of backpropagating action potentials or dendritic spike influences the plasticity results in the model. The dendritic effects are simulated by variable choices of voltage time course at the site of the synapse, i.e., without an explicit model of the spatial structure of the neuron. |
| first_indexed | 2024-12-14T01:20:13Z |
| format | Article |
| id | doaj.art-bb0f9b0e3feb407dad621f4360f82eb5 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-12-14T01:20:13Z |
| publishDate | 2010-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-bb0f9b0e3feb407dad621f4360f82eb52022-12-21T23:22:26ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632010-07-01210.3389/fnsyn.2010.000251355Voltage and spike timing interact in STDP - a unified modelClaudia Clopath0Claudia Clopath1Wulfram Gerstner2Laboratory of Computational Neuroscience,Center for Neuroprosthetics,Ecole Polytechnique Fédérale de Lausanne (EPFL)Université Paris DescartesLaboratory of Computational Neuroscience,Center for Neuroprosthetics,Ecole Polytechnique Fédérale de Lausanne (EPFL)A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on Spike-Timing Dependent Plasticity. The basic ingredient of the model is the correlation of presynaptic spike arrival with postsynaptic voltage. The local membrane voltage is used twice: a first term account for the instantaneous voltage and the second one on a low-pass filtered voltage trace. Spike-Timing effects emerge as a special case. We hypothesize that the voltage dependence can explain differential effects of STDP in dendrites, since the amplitude of time course of backpropagating action potentials or dendritic spike influences the plasticity results in the model. The dendritic effects are simulated by variable choices of voltage time course at the site of the synapse, i.e., without an explicit model of the spatial structure of the neuron.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00025/fullLTPSTDPsynaptic plasticityLTDModelcomputational neuroscience |
| spellingShingle | Claudia Clopath Claudia Clopath Wulfram Gerstner Voltage and spike timing interact in STDP - a unified model Frontiers in Synaptic Neuroscience LTP STDP synaptic plasticity LTD Model computational neuroscience |
| title | Voltage and spike timing interact in STDP - a unified model |
| title_full | Voltage and spike timing interact in STDP - a unified model |
| title_fullStr | Voltage and spike timing interact in STDP - a unified model |
| title_full_unstemmed | Voltage and spike timing interact in STDP - a unified model |
| title_short | Voltage and spike timing interact in STDP - a unified model |
| title_sort | voltage and spike timing interact in stdp a unified model |
| topic | LTP STDP synaptic plasticity LTD Model computational neuroscience |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00025/full |
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