Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films
In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, and the SF/PCL composite nanofiber films were characterized by the combined techniques of scanning electron microscopy (SEM), the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-07-01
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| Series: | Reviews on Advanced Materials Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rams-2022-0333 |
| _version_ | 1827899343933276160 |
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| author | Feng Yanping Jupei Zhang Dong Zhihong Tang Lu |
| author_facet | Feng Yanping Jupei Zhang Dong Zhihong Tang Lu |
| author_sort | Feng Yanping |
| collection | DOAJ |
| description | In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, and the SF/PCL composite nanofiber films were characterized by the combined techniques of scanning electron microscopy (SEM), the equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) and cell viability test. The results indicated several parameters, including the rotating roller speed, solution concentration, and SF/PCL ratio, affected SF/PCL composite nanofibers’ diameter size, distribution, and wettability. The SF/PCL composite nanofiber manifested a smaller fiber diameter and more uniform nanofibers than pure PCL nanofibers. The contact angle changed from 121 ± 2° of the neat pure PCL to full wetting of 40% SF/PCL composite nanofiber films at 2,000 rpm, indicating good hydrophilicity. Meanwhile, cells exhibit adhesion and proliferation on the composite nanofiber films. These results testified that SF/PCL composite nanofiber films may provide good wettability for cell adhesion and proliferation. It was suggested that optimized SF/PCL composite nanofiber films could be used as a potential biological dressing for skin wound healing. |
| first_indexed | 2024-03-12T23:16:45Z |
| format | Article |
| id | doaj.art-bb11312e81f8411aba9e6ddde6c3a54b |
| institution | Directory Open Access Journal |
| issn | 1605-8127 |
| language | English |
| last_indexed | 2024-03-12T23:16:45Z |
| publishDate | 2023-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews on Advanced Materials Science |
| spelling | doaj.art-bb11312e81f8411aba9e6ddde6c3a54b2023-07-17T05:25:57ZengDe GruyterReviews on Advanced Materials Science1605-81272023-07-01621pp. 4407441910.1515/rams-2022-0333Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber filmsFeng Yanping0Jupei Zhang1Dong Zhihong2Tang Lu3School of Mechanical Engineering, Chengdu University, Chengdu 610106, ChinaSchool of Mechanical Engineering, Chengdu University, Chengdu 610106, ChinaSchool of Mechanical Engineering, Chengdu University, Chengdu 610106, ChinaDepartment of Stomatology, The Affiliated Hospital of Chengdu University, Chengdu 610081, ChinaIn this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, and the SF/PCL composite nanofiber films were characterized by the combined techniques of scanning electron microscopy (SEM), the equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) and cell viability test. The results indicated several parameters, including the rotating roller speed, solution concentration, and SF/PCL ratio, affected SF/PCL composite nanofibers’ diameter size, distribution, and wettability. The SF/PCL composite nanofiber manifested a smaller fiber diameter and more uniform nanofibers than pure PCL nanofibers. The contact angle changed from 121 ± 2° of the neat pure PCL to full wetting of 40% SF/PCL composite nanofiber films at 2,000 rpm, indicating good hydrophilicity. Meanwhile, cells exhibit adhesion and proliferation on the composite nanofiber films. These results testified that SF/PCL composite nanofiber films may provide good wettability for cell adhesion and proliferation. It was suggested that optimized SF/PCL composite nanofiber films could be used as a potential biological dressing for skin wound healing.https://doi.org/10.1515/rams-2022-0333silk fibroinpolycaprolactonehydrophilicroller speedfiber diameter |
| spellingShingle | Feng Yanping Jupei Zhang Dong Zhihong Tang Lu Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films Reviews on Advanced Materials Science silk fibroin polycaprolactone hydrophilic roller speed fiber diameter |
| title | Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films |
| title_full | Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films |
| title_fullStr | Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films |
| title_full_unstemmed | Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films |
| title_short | Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films |
| title_sort | characterization biocompatibility and optimization of electrospun sf pcl composite nanofiber films |
| topic | silk fibroin polycaprolactone hydrophilic roller speed fiber diameter |
| url | https://doi.org/10.1515/rams-2022-0333 |
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