Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17057-z |
| _version_ | 1818403156780908544 |
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| author | Xiaoyong Du Ye Xiao Jia-Ming Huang Yao Zhang Ya-Nan Duan Heng Wang Chuan Shi Gen-Qiang Chen Xumu Zhang |
| author_facet | Xiaoyong Du Ye Xiao Jia-Ming Huang Yao Zhang Ya-Nan Duan Heng Wang Chuan Shi Gen-Qiang Chen Xumu Zhang |
| author_sort | Xiaoyong Du |
| collection | DOAJ |
| description | A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand. |
| first_indexed | 2024-12-14T08:19:47Z |
| format | Article |
| id | doaj.art-bb11eceb9a764f89b4c1f436bba6d895 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:19:47Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bb11eceb9a764f89b4c1f436bba6d8952022-12-21T23:09:50ZengNature PortfolioNature Communications2041-17232020-06-0111111010.1038/s41467-020-17057-zCobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acidsXiaoyong Du0Ye Xiao1Jia-Ming Huang2Yao Zhang3Ya-Nan Duan4Heng Wang5Chuan Shi6Gen-Qiang Chen7Xumu Zhang8Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyDepartment of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and TechnologyA large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.https://doi.org/10.1038/s41467-020-17057-z |
| spellingShingle | Xiaoyong Du Ye Xiao Jia-Ming Huang Yao Zhang Ya-Nan Duan Heng Wang Chuan Shi Gen-Qiang Chen Xumu Zhang Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids Nature Communications |
| title | Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids |
| title_full | Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids |
| title_fullStr | Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids |
| title_full_unstemmed | Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids |
| title_short | Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids |
| title_sort | cobalt catalyzed highly enantioselective hydrogenation of α β unsaturated carboxylic acids |
| url | https://doi.org/10.1038/s41467-020-17057-z |
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